Cordectomias vocais: Resultados e fatores preditores de recidiva e sobrevida
DOI:
https://doi.org/10.34631/sporl.868Palavras-chave:
carcinoma glótico, cordectomia Laser, recidiva, resultado oncológicoResumo
Objetivos: Avaliação de uma população submetida a cordectomia vocal com Laser CO2.
Desenho de estudo: Coorte retrospetivo.
Material e Métodos: Análise dos doentes com carcinoma epidermóide glótico pouco avançado, submetidos a cordectomia vocal durante 7 anos.
Resultados: Foram incluídos 48 doentes. A taxa de recidiva foi de 27.1%. Em 20.8% dos doentes foi diagnosticado um segundo tumor primário. As margens positivas foram o único fator prognóstico de recidiva estatisticamente significativo. A presença de um segundo tumor primário foi a única variável que se relacionou significativamente com a sobrevida.
Conclusões: A cordectomia vocal com Laser CO2 é uma cirurgia minimamente invasiva eficaz no tratamento de carcinomas glóticos pouco avançados. As margens positivas da lesão mostraram ser um fator estatisticamente significativo de recidiva, indicando o risco de persistência da neoplasia. Por influenciarem a sobrevida, deve existir um elevado índice de suspeição no diagnóstico de segundos tumores primários.
Referências
Michel J, Fakhry N, Duflo S, Lagier A. et al. Prognostic value of the status of resection margins after endoscopic laser cordectomy for T1a glottic carcinoma. Eur Ann Otorhinolaryngol Head Neck Dis. 2011 Dec;128(6):297-300. doi: 10.1016/j.anorl.2011.05.006
Osuch-Wójcikiewicz E, Rzepakowska A, Sobol M, Bruzgielewicz A. et al. Oncological outcomes of CO2 laser cordectomies for glottic squamous cell carcinoma with respect to anterior commissure involvement and margin status. Lasers Surg Med. 2019 Dec;51(10):874-881. doi: 10.1002/lsm.23130.
Remacle M, Eckel HE, Antonelli A, Brasnu D. et al. Endoscopic cordectomy. A proposal for a classification by the Working Committee, European Laryngological Society. Eur Arch Otorhinolaryngol. 2000;257(4):227-31. doi: 10.1007/s004050050228.
Mortuaire G, Francois J, Wiel E, Chevalier D. Local Recurrence after CO2 Laser Cordectomy for Early Glottic Carcinoma. Laryngoscope. 2006 Jan;116(1):101-5. doi: 10.1097/01.mlg.0000184524.23282.74.
Hartl D, Brasnu D. Contemporary Surgical Management of Early Glottic Cancer. Otolaryngol Clin North Am. 2015 Aug;48(4):611-25. doi: 10.1016/j.otc.2015.04.007.
Lee HS, Chun BG, Kim SW, Kim ST. et al. Transoral laser microsurgery for early glottic cancer as one-stage single-modality therapy: Transoral Laser Microsurgery. Laryngoscope. 2013 Nov;123(11):2670-4. doi: 10.1002/lary.24080.
Canis M, Ihler F, Martin A, Matthias C, Steiner W. Transoral laser microsurgery for T1a glottic cancer: Review of 404 cases. Head Neck. 2015 Jun;37(6):889-95. doi: 10.1002/hed.23688. Head Neck. 2015;37(6):889-895. doi:10.1002/hed.23688.
Fiz I, Mazzola F, Fiz F, Marchi F. et al. Impact of Close and Positive Margins in Transoral Laser Microsurgery for Tis–T2 Glottic Cancer. Front Oncol. 2017 Oct 16;7:245. doi: 10.3389/fonc.2017.00245.
Peretti G, Piazza C, Cocco D, De Benedetto L. et al. Transoral CO2 laser treatment for Tis-T3 glottic cancer: The University of Brescia experience on 595 patients. Head Neck. 2010 Aug;32(8):977-83. doi: 10.1002/hed.21278.
Charbonnier Q, Thisse AS, Sleghem L, Mouawad F. et al. Oncologic outcomes of patients with positive margins after laser cordectomy for T1 and T2 glottic squamous cell carcinoma: Local control after laser cordectomy. Head Neck. 2016 Dec;38(12):1804-1809. doi: 10.1002/hed.24518.
Lucioni M, Bertolin A, D’Ascanio L, Rizzotto G. Margin Photocoagulation in Laser Surgery for Early Glottic Cancer: Impact on Disease Local Control. Otolaryngol Head Neck Surg. 2012 Apr;146(4):600-5. doi: 10.1177/0194599811433270.
Agrawal N, Ha PK. Management of Early-Stage Laryngeal Cancer. Otolaryngol Clin North Am. 2008 Aug;41(4):757-69, vi-vii. doi: 10.1016/j.otc.2008.01.014.
Jackel M, Ambrosch P, Martin A, Steiner W. Impact of Re-resection for Inadequate Margins on the Prognosis of Upper Aerodigestive Tract Cancer Treated by Laser Microsurgery Laryngoscope. 2007 Feb;117(2):350-6. doi: 10.1097/01.mlg.0000251165.48830.89.
Fang T-J, Courey MS, Liao C-T, Yen T-C, Li H-Y. Frozen margin analysis as a prognosis predictor in early glottic cancer by laser cordectomy: Frozen Margin Analysis in Glottic Cancer Resection. Laryngoscope. 2013 Jun;123(6):1490-5. doi: 10.1002/lary.23875.
Chone CT, Yonehara E, Martins JEF, Altemani A, Crespo AN. Importance of Anterior Commissure in Recurrence of Early Glottic Cancer After Laser Endoscopic Resection. Arch Otolaryngol Head Neck Surg. 2007 Sep;133(9):882-7. doi: 10.1001/archotol.133.9.882.
Jacobi C, Freundorfer R, Reiter M. Transoral laser microsurgery in early glottic cancer involving the anterior commissure Eur Arch Otorhinolaryngol. 2019 Mar;276(3):837-845. doi: 10.1007/s00405-018-5261-4.
Steiner W, Ambrosch P, Rodel RMW, Kron M. Impact of Anterior Commissure Involvement on Local Control of Early Glottic Carcinoma Treated by Laser Microresection. Laryngoscope. 2004 Aug;114(8):1485-91. doi: 10.1097/00005537-200408000-00031.
Aluffi Valletti P, Taranto F, Chiesa A, Pia F, Valente G. Impact of resection margin status on oncological outcomes after CO2 laser cordectomy. Acta Otorhinolaryngol Ital. 2018 Feb;38(1):24-30. doi: 10.14639/0392-100X-870.
Vikram B. Changing Patterns of Failure in Advanced Head and Neck Cancer. Arch Otolaryngol . 1984 Sep;110(9):564-5. doi: 10.1001/archotol.1984.00800350006003.
León X, Ferlito A, Myer CM 3rd, Saffiotti U. et al. Second primary tumors in head and neck cancer patients. Acta Otolaryngol. 2002 Oct;122(7):765-78.
Wu X, Hu Y, Lippman S. Upper Aerodigestive Tract Cancers. in Neugut AI, Meadows AT, Robinson E, editors. Multiple Primary Cancers. Philadelphia: Lippincott Williams and Wilkins; 1999.
Jones AS, Morar P, Phillips DE, Field JK. et al. Second primary tumors in patients with head and neck squamous cell carcinoma. Cancer. 1995 Mar 15;75(6):1343-53. doi: 10.1002/1097-0142(19950315)75:6<1343::aid-cncr2820750617>3.0.co;2-t.
Atabek U, Mohit-Tabatabai MA, Raina S, Rush BF, Dasmahapatra KS. Lung cancer in patients with head and neck cancer. Incidence and long-term survival. Am J Surg. 1987 Oct;154(4):434-8. doi: 10.1016/0002-9610(89)90019-6.
Ritoe SC, Krabbe PF, Jansen MM, Festen J. et al. Screening for second primary lung cancer after treatment of laryngeal cancer. Laryngoscope. 2002 Nov;112(11):2002-8. doi: 10.1097/00005537-200211000-00017.
Loh KS, Brown DH, Baker JT, Gilbert RW. et al. A rational approach to pulmonary screening in newly diagnosed head and neck cancer. Head Neck. 2005 Nov;27(11):990-4. doi: 10.1002/hed.20261.
Downloads
Publicado
Como Citar
Edição
Secção
Licença
Direitos de Autor (c) 2021 Revista Portuguesa de Otorrinolaringologia e Cirurgia de Cabeça e Pescoço
Este trabalho encontra-se publicado com a Licença Internacional Creative Commons Atribuição-CompartilhaIgual 4.0.