Early stage supraglottic squamous cell carcinoma: 10 years’ experience of a portuguese oncological institution
DOI:
https://doi.org/10.34631/sporl.856Keywords:
supraglottic squamous cell carcinoma, early stages, T1/T2N0, Treatment, survivalAbstract
Objectives: Analyze the impact of the primary treatment on the oncological outcomes of the patients with supraglottic squamous cell carcinoma T1/T2N0 (SSCCT1/T2N0).
Design: Retrospective study.
Materials and methods: Revision of clinical records of the patients diagnosed with SSCCT1/T2N0 in an ENT Department of a portuguese oncological hospital between 01-01-2005 and 31-12-2014. Only the patients treated by partial laryngectomy or definitive radiotherapy (dRT) were included. The exclusion criteria were patients with synchronous head and neck tumors or previous history of larynx carcinoma.
To compare the oncological results, the patients treated with combination of surgery and radiotherapy were excluded. The patients were separated in two study groups: surgical group and dRT group.
Results: The surgical group achieved a higher total survival, but a lower disease-specific survival, compared to the dRT group.
Conclusions: Comparing the surgical group and the dRT group, no statistically significant difference was found in relation to survival.
References
Pfister DG, Spencer S, Adelstein D, Adkins D. et al. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Head and Neck Cancers- NCCN Evidence Blocks version 1.2020. National Comprehensive Cancer Network, Inc. [Internet]. 2020 Mar. Avaliable from:https://www.nccn.org: https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf
Amin MB, Edge S, Brookland R, Greene F, Brookland RK. et al. AJCC Cancer Staging Manual 8th Ed. Chicago: Springer. 2017. Available from: https://www.springer.com/gp/book/9783319406176
Pfister DG, Spencer S, Adelstein D, Adkins D. et al. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Head and Neck Cancers- NCCN Evidence Blocks version 1.2020. National Comprehensive Cancer Network, Inc. [Internet]. 2020 Mar. Avaliable from:https://www.nccn.org: https://www.nccn.org/professionals/physician_gls/pdf/head-and-neck.pdf
Sessions DG, Lenox J, Spector GJ. Supraglottic Laryngeal Cancer: Analysis of Treatment Results. Laryngoscope. 2005 Aug;115(8):1402-10. doi: 10.1097/01.MLG.0000166896.67924.B7.
Jones AS, Fish B, Fenton JE, Husband DJ. The treatment of early laryngeal cancers (T1-T2
N0): Surgery or Irradiation? Head Neck. 2004 Feb;26(2):127-35. doi: 10.1002/hed.10361.
Arshad H, Jayaprakash V, Gupta V, Cohan DM. et al. Survival Differences between Organ Preservation Surgery and Definitive Radiotherapy in Early Supraglottic Squamous Cell Carcinoma. Otolaryngol Head Neck Surg. 2014 Feb; 150(2):237-244. doi: 10.1177/0194599813512783.
Spriano G, Antognoni P, Piantanida R, Varinelli D. et al. Conservative Management of T1-T2N0 Supraglottic Cancer: A Retrospective Study. Am J Otolaryngol. 1997 Sep-Oct;18(5):299-305. doi:10.1016/s0196-0709(97)90023-5.
Patel KB, Nichols AC, Fung K, Yoo J, MacNeil D. Treatment of Early Stage Supraglottic Squamous Cell Carcinoma: Meta-analysis comparing Primary Surgery versus Primary Radiotherapy. J Otolaryngo Head and Neck Surg. 2018 Mar; 47(19):1-8. doi: 10.1186/s40463-018-0262-2
Cabanillas R, Rodrigo JP, Llorente JL, Suárez V. et al. Functional Outcomes of Transoral Laser Surgery of Supraglottic Carcinoma Compared with a Transcervical Approach. Head Neck. 2004 Aug;26(8):653-659. doi:10.1002/hed.20063
Peretti G, Piazza C, Cattaneo A, Benedetto L. et al. Comparison of Functional Outcomes After Endoscopic versus Open-Neck Supraglottic Laryngectomies. Ann Otol Rhinol Laryngol. 2006 Nov; 115(11):827-32. doi:10.1177/000348940611501106.
Cagli S, Yuce I, Yigitbasi OG, Guney E. Is Routine Bilateral Neck Dissection Absolutely Necessary in the Management of N0 Neck in Patients with Supraglottic Carcinoma?. Eur Arch Otorhinolaryngol. 2007 Dec; 264(12):1453-7. doi: 10.1007/s00405-007-0384-z.
Redaelli de Zinis LO, Nicolai P, Tomenzoli D, Ghizzardi D. et al. The Distribution of Lymph Node Metastases in Supraglottic Squamous Cell Carcinoma: Therapeutic implications. Head Neck. 2002 Oct; 24(10):913-20. doi: 10.1002/hed.10152.
Deganello A, Gitti G, Meccariello G, Parrinello G, et al. Effectiveness and Pitfalls of Elective Neck Dissection in N0 Laryngeal Cancer. Acta Otorhinolaryngol Ital. 2011 Aug; 31:216-221. Available from: https://www.actaitalica.it/issues/2011/4-11/03%20Deganello.pdf
Cummings CW. Incidence of Nodal Metastases in T2 Supraglottic Carcinoma. Arch Otolayngol. 1974 April; 99(4):268-9. doi:10.1001/archotol.1974.00780030278008.
Langroudi MM, Amirzargar B, Amali A, Sadeghi M. et al. Rate of Occult Cervical Lymph Node Involvement in Supraglottic Squamous Cell Carcinoma. Iran J Otorhinolaryngol. 2017 May; 29(3):133-136. Avaliable from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5448027/pdf/ijo-29-133.pdf
Zhang Y, Xu S, Liu W, Xang K, et al. Rational choice of neck dissection in clinically N0 patients with supraglottic cancer. Head Neck. 2020 Mar;42(3):365-373. doi: 10.1002/hed.26014
Petrovic Z, Arsovic N, Trivic A. Selective neck dissection for no Neck Supraglottic Carcinoma. International Congress Series. 2003 Oct;1240:853-858. doi:10.1016/s0531-5131(03)00715-5.
Shah JP, Tollefsen HR. Epidermoid Carcinoma of the Supraglottic Larynx - Role of Neck Dissection in Initial Surgical Treatment. Am J Surg. 1974 Oct; 128(4):494-9. doi:10.1016/0002-9610(74)90262-1.
Lutz CK, Johnson JT, Wagner RL, Myers EN. Supraglottic Carcinoma: Patterns of Recurrence. Ann Otol Rhinol Laryngol. 1990 Jan; 99(1):12-7. doi: 10.1177/000348949009900103
Shi Y, Zhou L, Tao L, Zhang M. et al. Management of the N0 neck in Patients with Laryngeal Squamous Cell Carcinoma. Acta Otolaryngol. 2019 Oct; 139(10):908-912. doi: 10.1080/00016489.2019.1641219
Ambrosch P, Gonzalez-Donate M, Fazel A, Schmalz C. et al. Transoral Laser Microsurgery for Supraglottic Cancer. Front Oncol. 2018 May; 8: 158. doi:10.3389/fonc.2018.00158.
Canis M, Martin A, Ihler F, Wolff HA. et al. Results of Transoral Laser Microsurgery for Supraglottic Carcinoma in 277 patients. Eur Arch Otorhinolaryngol. 2013 Aug; 270(8):2315-26. doi:10.1007/s00405-012-2327-6.
Mendenhall WM, Parsons JT, Mancuso AA, Stringer SP. et al. Radiotherapy for squamous cell carcinoma of the supraglottic larynx: an alternative to surgery. Head Neck. 1996 Jan-Feb; 18(1):24-35. doi:10.1002/(SICI)1097-0347(199601/02)18:1<24::AID-HED4>3.0.CO;2-0.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2021 Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.