Treatment of laryngeal cancer in a tertiary hospital - survival analysis of 10 years of experience

Authors

DOI:

https://doi.org/10.34631/sporl.2133

Keywords:

Laryngeal Neoplasms, Survival Rate, Risk Factors, Prognosis

Abstract

Laryngeal cancer is the second most common neoplasm of the upper aero-digestive tract. The aim of this study is to epidemiologically characterize the patients with laryngeal cancer diagnosed and treated at our institution, as well as to carry out an analysis of their survival.

A retrospective study was conducted which included 150 patients with a mean age at diagnosis of 62.8 ± 9.5 years, 145 of whom were male, 92.5% had smoking habits and 83.7% had alcohol habits.

Patients with early stages at diagnosis (0, I and II) had a disease-related survival rate of 92% at 5 years compared to patients with advanced stages (III or IV), who had a survival rate of 58%. 

As expected, patient survival varied significantly between all the different prognostic groups defined by the American Joint Committee on Cancer (AJCC) (p<0.001).

Our study shows that patients with laryngeal carcinoma diagnosed and treated at our center have an epidemiology and survival rate comparable to those reported in the literature.

References

Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A. et al. Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021 May;71(3):209-249. doi: 10.3322/caac.21660.

Steuer CE, El-Deiry M, Parks JR, Higgins KA, Saba NF. An update on larynx cancer. CA Cancer J Clin. 2017 Jan;67(1):31-50. doi: 10.3322/caac.21386.

OCDE/Observatório Europeu dos Sistemas e Políticas de Saúde (2021), Portugal: Perfil de Saúde do País 2021, Estado da Saúde na UE, OCDE, Paris/Observatório Europeu dos Sistemas e Políticas de Saúde, Bruxelas. Disponível em: https://health.ec.europa.eu/system/files/2021-12/2021_chp_pt_portuguese.pdf

Serviço de Intervenção nos Comportamentos Aditivos e nas Dependências (SICAD), Direção de Serviços de Monitorização e Informação (DMI) DodEseIaoD. SINOPSE ESTATÍSTICA 2021 – Álcool.

Amin MB, Edge S, Greene F, Byrd DR, Brookland RK, Washington MK, et al. AJCC Cancer Staging Manual. 8th ed. Springer International Publishing: American Joint Commission on Cancer. 2017.

Li MM, Zhao S, Eskander A, Rygalski C, Brock G, Parikh AS. et al. Stage migration and survival trends in laryngeal cancer. Ann Surg Oncol. 2021 Nov;28(12):7300-7309. doi: 10.1245/s10434-021-10318-1.

Nahavandipour A, Jakobsen KK, Gronhoj C, Hebbelstrup Jensen D, Kim Schmidt Karnov K, Klitmoller Agander T. et al. Incidence and survival of laryngeal cancer in Denmark: a nation-wide study from 1980 to 2014. Acta Oncol. 2019 Jul;58(7):977-982. doi: 10.1080/0284186X.2019.1572923.

Timme DW, Jonnalagadda S, Patel R, Rao K, Robbins KT. Treatment selection for T3/T4a laryngeal cancer: chemoradiation versus primary surgery. Ann Otol Rhinol Laryngol. 2015 Nov;124(11):845-51. doi: 10.1177/0003489415588130.

Kohler HF, Carvalho GB, Kowalski LP. Treatment results for stage III laryngeal cancer: analysis of a populational database using propensity scores. Int Arch Otorhinolaryngol. 2021 Nov 3;26(3):e370-e379. doi: 10.1055/s-0041-1726042.

Arboleda LPA, Neves AB, Kohler HF, Vartanian JG, Candelária LM, Borges MF. et al. Overview of glottic laryngeal cancer treatment recommendation changes in the NCCN guidelines from 2011 to 2022. Cancer Rep (Hoboken). 2023 Aug;6(8):e1837. doi: 10.1002/cnr2.1837.

Stokes WA, Jones BL, Bhatia S, Oweida AJ, Bowles DW, Raben D. et al. A comparison of overall survival for patients with T4 larynx cancer treated with surgical versus organ-preservation approaches: a national cancer data base analysis. Cancer. 2017 Feb 15;123(4):600-608. doi: 10.1002/cncr.30382.

da Cunha Costa TF, Cardoso E. Carcinoma da laringe – 7 anos de experiência num hospital central. Port J ORL [Internet]. 2017 Oct 30 [cited 2023 Dec 5];54(4):255-9. Available from: https://journalsporl.com/index.php/sporl/article/view/657

Published

2024-06-04

How to Cite

Barreto, J., Marques Gomes, P., Duarte, D., & Viana, M. (2024). Treatment of laryngeal cancer in a tertiary hospital - survival analysis of 10 years of experience. Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery, 62(2), 151–157. https://doi.org/10.34631/sporl.2133

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Section

Original Article