Basaloid squamous cell carcinoma of the larynx: 16 years of experience at the otorhinolaryngology department of IPO-LFG

Abstract

Objectives: Identify prognostic factors of basaloid squamous cell carcinoma of the larynx (BSCCL); evaluate survival according to staging, sublocalization and treament.

Study design: Retrospective

Material & methods: Cases of BSCCL at IPO-LFG(2003-2019) were identified. Sociodemographic data, staging and treatment were registered. Overall survival(OS) and disease free survival(DFS) were calculated. We used qui-square test(categorical variables), T test(continuous variable) and Kaplan-Meier method(survival comparison).

Results and Conclusions: 43 individuals(mean age: 59,7 years; 97,7% males). Staging: a) local: T1 (7%), T2 (18,6%), T3 (27,9%), T4a (46,5%); b) regional: N+(60,5%); c) distance: M0 (95,3%). Localization: supraglottis (58,1%); glottis (25,6%); transglottic (16,3%). 95,3% treated with curative intent, of those, 95,2% underwent surgery(70,7% total laryngectomy; 17,1% partial supraglottic laryngectomy; 7,3% cordectomy); 2,4% RT; 2,4% CRT. 87,2% of operated underwent bilateral neck dissection. 92,3% of operated underwent adjuvant CRT/RT. DFS at 2 years was similar for T1/T2 (63,6%) and T3/T4a (63,3%). Individuals N0 at presentation showed DFS at 2 years (87,5%) > N+(48%); p=0,017. DFS at 2 years in supraglottic tumours (52,0%) was inferior to glottic (90,9%); p=0,031.

BSCCL is frequently diagnosed in advanced stages. Supraglottic localization and N+ neck are the main bad prognosis factors.