Upper aerodigestive tract bleeding in head and neck - a tertiary Center Reality
DOI:
https://doi.org/10.34631/sporl.3145Keywords:
tumor hemorrhage, squamous cell carcinoma, head and neck cancerAbstract
Objective: To characterize hospital admissions due to tumoral hemorrhage from head and neck squamous cell carcinoma (SCC) in a tertiary center.
Study design: Retrospective.
Material and Methods: Review of clinical files with a diagnosis of oral cavity hemorrhage (ICD 10 R04.1) associated with head and neck SCC, from 2018 to 2023.
Results: 36 admissions were analyzed. The most frequent tumor location was the oropharynx (61%). Most of the tumors were stage IV (89%). 50% of patients had undergone CRT. With regard to hemostasis treatment, 17% received local measures; 14% also required systemic antifibrinolytic therapy; in 36% tamponade was performed. Surgical hemostasis was required in 17% of episodes and 11% underwent hemostatic radiotherapy. 25% needed emergent tracheostomy.
Conclusions: Factors such as oropharyngeal tumor location, stage IV and previous CRT were prevalent in patients requiring hospitalization for tumor hemorrhage.
Downloads
References
Mody MD, Rocco JW, Yom SS, Haddad RI, Saba NF. Head and neck cancer. Lancet. 2021 Dec 18;398(10318):2289-2299. doi: 10.1016/S0140-6736(21)01550-6.
Global Cancer Observatory [Internet]. WHO: International Agency for Research on Cancer, 2020. Available from: https://gco.iarc.fr/
Saldanha E, Jain A, Patel D, Joseph B, Ghosh S, Dhakad V. et al. Bleeding in head and neck malignancy: institution based management and review. [Internet] Research Square 2021 Mar 9; Available from: https://www.researchsquare.com/article/rs-237519/v1.pdf
Yen CC, Ho CF, Wu CC, Tsao YN, Chung-Hsien Chaou, Chen SY. et al. In-hospital and long-term outcomes in patients with head and neck cancer bleeding. Medicina (Kaunas). 2022 Jan 25;58(2):177. doi: 10.3390/medicina58020177.
Vilas Boas PP, de Castro-Afonso LH, Monsignore LM, Nakiri GS, de Mello-Filho FV, Abud DG. Endovascular management of patients with head and neck cancers presenting with acute hemorrhage: a single-center retrospective study. Cardiovasc Intervent Radiol. 2017 Apr;40(4):510-519. doi: 10.1007/s00270-016-1550-8.
Wang CK, Ho CF, Niu KY, Wu CC, Chang YC, Hsiao CH. et al. Risk factors for rebleeding and long-term outcomes in patients with head and neck cancer bleeding: a multicenter study. BMC Cancer. 2022 Aug 2;22(1):841. doi: 10.1186/s12885-022-09945-y.
Bergamini C, Ferris RL, Xie J, Mariani G, Ali M, Holmes WC. et al. Bleeding complications in patients with squamous cell carcinoma of the head and neck. Head Neck. 2021 Sep;43(9):2844-2858. doi: 10.1002/hed.26772.
Yen CC, Yeh H, Ho CF, Hsiao CH, Niu KY, Yeh CC. et al. Risk factors for 30-day mortality in patients with head and neck cancer bleeding in the emergency department. Am J Emerg Med. 2022 Aug:58:9-15. doi: 10.1016/j.ajem.2022.05.008.
Self EM, Bumpous J, Ziegler C, Wilson L, Potts K. Risk factors for hemorrhage after chemoradiation for oropharyngeal squamous cell carcinoma. JAMA Otolaryngol Head Neck Surg. 2013 Apr;139(4):356-61. doi: 10.1001/jamaoto.2013.103.
Harris DG, Noble SIR. Management of terminal hemorrhage in patients with advanced cancer: a systematic literature review. J Pain Symptom Manage. 2009 Dec;38(6):913-27. doi: 10.1016/j.jpainsymman.2009.04.027.
Kristensen M, McGuire BB. Managing and securing the bleeding upper airway: a narrative review. Can J Anaesth. 2020 Jan;67(1):128-140. doi: 10.1007/s12630-019-01479-5.
Cannavale A, Corona M, Nardis P, De Rubeis G, Cannavale G, Santoni M. et al. Computed Tomography Angiography findings can predict massive bleeding in head and neck tumours. Eur J Radiol. 2020 Apr:125:108910. doi: 10.1016/j.ejrad.2020.108910.
Song J, Brown C, Dennis K, Gaudet M, Haddad A. Palliative radiotherapy for haemostasis in malignancy: a systematic review. Clin Oncol (R Coll Radiol). 2023 Sep;35(9):e478-e488. doi: 10.1016/j.clon.2023.06.007.
Guhlich M, Maag TE, Dröge LH, Hille A, Donath S, Bendrich S. et al. Hemostatic radiotherapy in clinically significant tumor-related bleeding: excellent palliative results in a retrospective analysis of 77 patients. Radiat Oncol. 2023 Dec 20;18(1):203. doi: 10.1186/s13014-023-02391-5.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2026 Carolina Cardoso Arede, Miguel Arede Antunes, João Rosa, Mafalda Oliveira, Paulo Pereira, Ana Rita Santos, Leonel Luís

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.



