Surgery vs. chemoradiotherapy in the treatment of locally advanced squamous cell carcinoma of the hypopharynx – survival analysis and prognostic factors
DOI:
https://doi.org/10.34631/sporl.3118Keywords:
Surgery, Chemoradiotherapy, Squamous cell carcinoma, Hypopharynx, Overall survival, Disease-free survival, Organ-preserving treatmentAbstract
This unicentric retrospective observational study analyzed 132 individuals with squamous cell carcinoma of the hypopharynx in T3 and T4a stages, diagnosed between 2017 and 2021, with the aim of comparing survival outcomes in individuals treated with initial surgery vs. definitive chemoradiotherapy (CRT) and determining prognostic predictors. The median follow-up time was 31.5 months, with a median age of 61 years. No significant differences were found in overall survival (OS) (49.3% vs. 46.5%, p=0.912) or disease-free survival (DFS) (57.8% vs. 56.6%, p=0.646) between the treatment types. T and N classifications were independent predictors of OS. The study suggests that the type of initial treatment does not substantially affect prognosis in this patient group.
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Copyright (c) 2025 Luís André Baptista, Mariana Cardoso, Carolina Arede, Filipe Jacinto, Margarida Pereira, Joana Guincho, Beatriz Rodrigues, Carlota Sousa, Sara Ramalho, Pedro Montalvão, Pedro Escada, Miguel Magalhães
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