Merkel Cell Carcinoma - A clinical case report
DOI:
https://doi.org/10.34631/sporl.3073Keywords:
Merkel cell carcinoma, Cervical mass, cutaneous lesionAbstract
Aim: To report a case of Merkel cell carcinoma in a patient who presented with a rapidly growing cervical mass.
Background: Merkel cell carcinoma is a rare and aggressive cutaneous malignant tumor, with a high recurrence rate and propensity for metastasis. Our goal is to alert and raise awareness among otorhinolaryngologists about this entity, especially in the differential diagnosis of neck masses.
Case description: A 77-year-old woman presented to the clinic due to rapidly growing left cervical swelling. Following fine-needle aspiration cytology and incisional biopsy, Merkel cell carcinoma was diagnosed. The patient died 6 months after the initial presentation.
Conclusion: Merkel cell carcinoma is a rare entity with a rapid and aggressive evolution which normally manifests as a cutaneous lesion of the head and neck but should be included in the differential diagnosis of cervical masses.
Downloads
References
Albores-Saavedra J, Batich K, Chable-Montero F, Sagy N, Schwartz AM, Henson DE. Merkel cell carcinoma demographics, morphology, and survival based on 3870 cases: a population based study. J Cutan Pathol. 2010 Jan;37(1):20-7. doi: 10.1111/j.1600-0560.2009.01370.x.
Heath M, Jaimes N, Lemos B, Mostaghimi A, Wang LC, Peñas PF. et al. Clinical characteristics of Merkel cell carcinoma at diagnosis in 195 patients: the AEIOU features. J Am Acad Dermatol. 2008 Mar;58(3):375-81. doi: 10.1016/j.jaad.2007.11.020.
Santos-Juanes J, Fernández-Vega I, Fuentes N, Galache C, Coto-Segura P, Vivanco B. et al. Merkel cell carcinoma and Merkel cell polyomavirus: a systematic review and meta-analysis. Br J Dermatol. 2015 Jul;173(1):42-9. doi: 10.1111/bjd.13870.
Watkinson JC, Clarke R. Scott-Brown’s Otorhinolaryngology and Head and Neck Surgery. Vol 3. Head and neck surgery, plastic surgery. Boca Raton: CRC Press; 2018.
Poulsen M, Macfarlane D, Veness M, Estall V, Hruby G, Kumar M. et al. Prospective analysis of the utility of 18-FDG PET in Merkel cell carcinoma of the skin: A Trans Tasman Radiation Oncology Group Study, TROG 09:03. J Med Imaging Radiat Oncol. 2018 Jun;62(3):412-419. doi: 10.1111/1754-9485.12705.
Singh N, Alexander NA, Lachance K, Lewis CW, McEvoy A, Akaike G. et al. Clinical benefit of baseline imaging in Merkel cell carcinoma: Analysis of 584 patients. J Am Acad Dermatol. 2021 Feb;84(2):330-339. doi: 10.1016/j.jaad.2020.07.065.
Joshi AS. Merkel Cell Tumors of the Head and Neck [Internet] [updated 2023 march 17] Available from: https://emedicine.medscape.com/article/853565-overview
Vandeven N, Lewis CW, Makarov V, Riaz N, Paulson KG, Hippe D. et al. Merkel cell carcinoma patients presenting without a primary lesion have elevated markers of immunity, higher tumor mutation burden, and improved survival. Clin Cancer Res. 2018 Feb 15;24(4):963-971. doi: 10.1158/1078-0432.CCR-17-1678.
9. Bhatia S, Nghiem P, Veeranki SP, Vanegas A, Lachance K, Tachiki L. et al. Real-world clinical outcomes with avelumab in patients with Merkel cell carcinoma treated in the USA: a multicenter chart review study. J Immunother Cancer. 2022 Aug;10(8):e004904. doi: 10.1136/jitc-2022-004904.
D'Angelo SP, Lebbé C, Mortier L, Brohl AS, Fazio N, Grob JJ. et al. First-line avelumab in a cohort of 116 patients with metastatic Merkel cell carcinoma (JAVELIN Merkel 200): primary and biomarker analyses of a phase II study. J Immunother Cancer. 2021 Jul;9(7):e002646. doi: 10.1136/jitc-2021-002646.
Harms KL, Healy MA, Nghiem P, Sober AJ, Johnson TM, Bichakjian CK. et al. Analysis of prognostic factors from 9387 Merkel cell carcinoma cases forms the basis for the New 8th Edition AJCC Staging System. Ann Surg Oncol. 2016 Oct;23(11):3564-3571. doi: 10.1245/s10434-016-5266-4.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Leonor Oliveira, Ana Miguel Couto, Rafael Pires, Jorge Oliveira, Carla André, Luís Antunes

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.