Endoscopic endonasal pituitary surgery: experience of the Local Health Unit of Algarve
DOI:
https://doi.org/10.34631/sporl.3072Keywords:
Pituitary adenomas, Endoscopic endonasal transsphenoidal surgeryAbstract
Objectives: To conduct a case analysis of patients with pituitary adenomas who underwent endoscopic endonasal transsphenoidal surgery.
Study design: Retrospective descriptive study.
Material and Methods: Patients with pituitary adenomas (n=30) who underwent endoscopic endonasal transsphenoidal surgery at ULS do Algarve, Faro Unit, between 2016 and 2022, were evaluated for gender, age, symptoms, size, extent and histology of the lesion, recurrence/persistence rate, and complications.
Results: The main clinical presentation of the patients was decreased visual acuity. Gonadotrophic pituitary adenoma was the most common pathology. Transient diabetes insipidus was the most frequent postoperative complication. We achieved a resolution rate in terms of tumor resection and chiasmatic compression mass effect in 83% of cases, with most persistences classified as residual lesions.
Conclusions: The removal of pituitary adenomas using the endoscopic endonasal transsphenoidal approach proved to be effective and safe, with low morbidity and high tumor remission rates.
Downloads
References
McNeill KA. Epidemiology of brain tumors. Neurol Clin. 2016 Nov;34(4):981-998. doi: 10.1016/j.ncl.2016.06.014.
Ezzat S, Asa SL, Couldwell WT, Barr CE, Dodge WE, Vance ML. et al. The prevalence of pituitary adenomas: a systematic review. Cancer. 2004 Aug 1;101(3):613-9. doi: 10.1002/cncr.20412.
Banskota S, Adamson DC. Pituitary adenomas: from diagnosis to therapeutics. Biomedicines. 2021 Apr 30;9(5):494. doi: 10.3390/biomedicines9050494.
Molitch ME. Diagnosis and treatment of pituitary adenomas: a review. JAMA. 2017 Feb 7;317(5):516-524. doi: 10.1001/jama.2016.19699.
Lindholm J. A century of pituitary surgery: Schloffer’s legacy. Neurosurgery. 2007 Oct;61(4):865-7; discussion 867-8. doi: 10.1227/01.NEU.0000298916.09377.05.
Hardy J, Lalonde JL. Removal by trans-sphenoidal route of a giant craniopharyngioma. Union Med Can. 1963 Oct:92:1124-9.
Stammberger H. Endoscopic endonasal surgery--concepts in treatment of recurring rhinosinusitis. Part II. Surgical technique. Otolaryngol Head Neck Surg. 1986 Feb;94(2):147-56. doi: 10.1177/019459988609400203.
Jankowski R, Auque J, Simon C, Marchal JC, Hepner H, Wayoff M. Endoscopic pituitary tumor surgery. Laryngoscope. 1992 Feb;102(2):198-202. doi: 10.1288/00005537-199202000-00016.
Carrau RL, Jho H, Ko Y. Transnasal-transsphenoidal endoscopic surgery of the pituitary gland. Laryngoscope. 1996 Jul;106(7):914-8. doi: 10.1097/00005537-199607000-00025.
Jho HD, Carrau RL. Endoscopic endonasal transsphenoidal surgery: experience with 50 patients. J Neurosurg. 1997 Jul;87(1):44-51. doi: 10.3171/jns.1997.87.1.0044.
DeKlotz TR, Chia SH, Lu W, Makambi KH, Aulisi E, Deeb Z. Meta‐analysis of endoscopic versus sublabial pituitary surgery. Laryngoscope. 2012 Mar;122(3):511-8. doi: 10.1002/lary.22479.
Tritos NA, Miller KK. Diagnosis and management of pituitary adenomas: a review. JAMA. 2023 Apr 25;329(16):1386-1398. doi: 10.1001/jama.2023.5444.
Cooper O, Melmed S. Subclinical hyperfunctioning pituitary adenomas: the silent tumors. Best Pract Res Clin Endocrinol Metab. 2012 Aug;26(4):447-60. doi: 10.1016/j.beem.2012.01.002.
Pivonello R, Isidori AM, De Martino MC, Newell-Price J, Biller BM, Colao A. Complications of Cushing’s syndrome: state of the art. Lancet Diabetes Endocrinol. 2016 Jul;4(7):611-29. doi: 10.1016/S2213-8587(16)00086-3.
van Furth WR, de Vries F, Lobatto DJ, Kleijwegt MC, Schutte PJ, Pereira AM. et al. Endoscopic surgery for pituitary tumors. Endocrinol Metab Clin North Am. 2020 Sep;49(3):487-503. doi: 10.1016/j.ecl.2020.05.011.
Cappabianca P, Cavallo LM, Colao A, de Divitiis E. Surgical complications associated with the endoscopic endonasal transsphenoidal approach for pituitary adenomas. J Neurosurg. 2002 Aug;97(2):293-8. doi: 10.3171/jns.2002.97.2.0293.
Dehdashti AR, Ganna A, Karabatsou K, Gentili F. Pure endoscopic endonasal approach for pituitary adenomas: early surgical results in 200 patients and comparison with previous microsurgical series. Neurosurgery. 2008 May;62(5):1006-15; discussion 1015-7. doi: 10.1227/01.neu.0000325862.83961.12.
Tabaee A, Anand VK, Barrón Y, Hiltzik DH, Brown SM, Kacker A. et al. Endoscopic pituitary surgery: a systematic review and meta-analysis. J Neurosurg. 2009 Sep;111(3):545-54. doi: 10.3171/2007.12.17635.
Berker M, Hazer DB, Yücel T, Gürlek A, Cila A, Aldur M. et al. Complications of endoscopic surgery of the pituitary adenomas: analysis of 570 patients and review of the literature. Pituitary. 2012 Sep;15(3):288-300. doi: 10.1007/s11102-011-0368-2.
Schreckinger M, Walker B, Knepper J, Hornyak M, Hong D, Kim JM. et al. Post-operative diabetes insipidus after endoscopic transsphenoidal surgery. Pituitary. 2013 Dec;16(4):445-51. doi: 10.1007/s11102-012-0453-1.
Kassam AB, Thomas A, Carrau RL, Snyderman CH, Vescan A, Prevedello D. et al. Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap. Neurosurgery. 2008 Jul;63(1 Suppl 1):ONS44-52; discussion ONS52-3. doi: 10.1227/01.neu.0000297074.13423.f5.
Hadad G, Bassagasteguy L, Carrau RL, Mataza JC, Kassam A, Snyderman CH. et al. A novel reconstructive technique after endoscopic expanded endonasal approaches: vascular pedicle nasoseptal flap. Laryngoscope. 2006 Oct;116(10):1882-6. doi: 10.1097/01.mlg.0000234933.37779.e4.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2025 Filipe V. Jacinto, Vítor Oliveira, Pedro Abreu, Artur Lourenço, Luís Freitas, Ilídio Gonçalves

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.