Intensity modulated radiation therapy (IMRT) - illustration of the technique, indications and advantages
DOI:
https://doi.org/10.34631/sporl.236Keywords:
Intensity modulated radiation therapy, advantagesAbstract
IMRT is a state-of-the-art cancer treatment method that delivers high doses of radiation directly to cancer cells in a very targeted way, much more precisely than is possible with conventional radiotherapy. IMRT can deliver higher radiation doses directly to cancer cells while sparing more of the surrounding healthy tissue. This has important advantages in head and neck cancers as it allows the beams to hit their target area while missing the surrounding structures, minimizing acute and late side effects.
The purpose of this article is to describe the IMRT technique, its clinical applications and advantages, when comparing to the conventional Radiotherapy.
References
APISARNTHANARAX S, ELLIOTT DD, EL-NAGGAR AK ET AL. DETERMINING OPTIMAL CLINICAL TARGET VOLUME MARGINS IN HEAD-AND-NECK CANCER BASED ON MICROSCOPIC EXTRACAPSULAR EXTENSION OF METASTATIC NECK NODES. INT J RADIAT ONCOL BIOL PHYS, 2006; 64: 678-683
BLANCO AI, CHAO KSC. INTENSITY-MODULATED RADIATION THERAPY AND PROTECTION OF NORMAL TISSUE FUNCTION IN HEAD AND NECK CANCER. IN PRINCIPLES AND PRACTICE OF RADIATION ONCOLOGY: UPDATES. NEW YORK: LIPPINCOTT WILLIAMS & WILKINS HEALTHCARE, 2002;3
CHAO KS, LOW DA, PEREZ CA, PURDY JA. INTENSITY-MODULATED RADIATION THERAPY IN HEAD AND NECK CANCERS. THE MALLINCKRODT EXPERIENCE. INT J CANCER, 2001; 90: 92-103
CHAO KS, DEASY JO, MARKMAN J, HAYNIE J ET AL. A PROSPECTIVE STUDY OF SALIVARY FUNCTION SPARING IN PATIENTS WITH HEAD-AND-NECK CANCERS RECEIVING INTENSITY-MODULATED OR THREE-DIMENSIONAL RADIATION THERAPY. INITIAL RESULTS. INT J RADIAT ONCOL BIOL PHYS, 2001; 49: 907-916
CHAO KS, WIPPOLD FJ, OZYGIT G, TRAN BN ET AL. DETERMINATION AND DELINEATION OF NODAL TARGET VOLUMES FOR HEAD-AND-NECK CANCER BASED ON PATTERNS OF FAILURE IN PATIENTS RECEIVING DEFINITIVE AND POSTOPERATIVE IMRT. INT J RADIAT ONCOL BIOL PHYS, 2002; 53(5): 1174-1184
CHAO KS, OZYIGIT G, TRAN BN ET AL. PATTERNS OF FAILURE IN PATIENTS RECEIVING DEFINITIVE AND POSTOPERATIVE IMRT FOR HEAD-AND-NECK CANCER. INT J RADIAT ONCOL BIOL PHYS, 2003; 55: 312-321
EISBRUCH A, KIM HM, TERRELL JE, MARSH LH ET AL. XEROSTOMIA AND ITS PREDICTORS FOLLOWING PAROTID-SPARING IRRADIATION OF HEAD- AND-NECK CANCER. INT J RADIAT ONCOL BIOL PHYS, 2001; 50: 695-704
EISBRUCH A, MARSH LH, DAWSON LA ET AL. RECURRENCES NEAR BASE OF SKULL AFTER IMRT FOR HEAD-AND-NECK CANCER: IMPLICATIONS FOR TARGET DELINEATION IN HIGH NECK AND FOR PAROTID GLAND SPARING. INT J RADIAT ONCOL BIOL PHYS, 2004; 59: 28-42
FRANK SJ, CHAO KS, SCHWARTZ DL ET AL. TECHNOLOGY INSIGHT: PET AND PET/CT IN HEAD AND NECK TUMOR STAGING AND RADIATION THERAPY PLANNING. NAT CLIN PRACT ONCOL, 2005; 2: 526-533
GRÉGOIRE V, DE NEVE W, EISBRUCH A, LEE N ET AL. INTENSITY-MO- DULATED RADIATION THERAPY FOR HEAD AND NECK CARCINOMA. THE ONCOLOGIST, 2007; 12: 555-564
HUNT MA, ZELEFSKY MJ, WOLDEN S, CHUI CS ET AL. TREATMENT PLAN- NING AND DELIVERY OF INTENSITY-MODULATED RADIATION THERAPY FOR PRIMARY NASOPHARYNX CANCER. INT J RADIAT ONCOL BIOL PHYS, 2002; 49: 623-632
PAULINO AC, KOSHY M, HOWELL R ET AL. COMPARISON OF CT- AND FDG-PET-DEFINED GROSS TUMOR VOLUME IN INTENSITY-MODULATED RADIOTHERAPY FOR HEAD-AND-NECK CANCER. INT J RADIAT ONCOL BIOL PHYS, 2005; 61: 1385-1392
POW EH, KWONG DL, MCMILLAN AS ET AL. XEROSTOMIA AND QUALITY OF LIFE AFTER INTENSITY-MODULATED RADIOTHERAPY VS. CONVENTIONAL RADIOTHERAPY FOR EARLY-STAGE NASOPHARYNGEAL CARCINOMA: INITIAL REPORT ON A RANDOMIZED CONTROLLED CLINICAL TRIAL. INT J RADIAT ONCOL BIOL PHYS, 2006; 66: 981-991
TEH BS, WOO SY, BUTLER EB. INTENSITY MODULATED RADIATION THE- RAPY (IMRT): A NEW PROMISING TECHNOLOGY IN RADIATION ONCOLOGY. THE ONCOLOGIST, 1999; 4: 433-442
WITHERS HR, TAYLOR JM, MACIEJEWSKI B. THE HAZARD OF ACCELERA- TED TUMOR CLONOGEN REPOPULATION DURING RADIOTHERAPY. ACTA ONCOL, 1988; 27: 131-146
WU QM, MANNING M, SCHMIDT-ULLRICH R, MOHAN R. THE POTENTIAL FOR SPARING OF PAROTIDS AND ESCALATION OF BIOLOGICALLY EFFECTIVE DOSE WITH INTENSITY-MODULATED RADIATION TREATMENTS OF HEAD AND NECK CANCERS: A TREATMENT DESIGN STUDY. INT J RADIAT ONCOL BIOL PHYS, 2000; 46: 195-205