Radio-guided surgery in hyperparathyroidism
DOI:
https://doi.org/10.34631/sporl.919Keywords:
Radio-guided surgery, Hyperparathyroidism, Scintigraphy, gamma camera, parathormone, Mci MIBI, SPECT /TCAbstract
Objectives: To assess the utility of radio-guided surgery (CRG) as a surgical method for the different forms of presentation of hyperparathyroidism.
Study design: A retrospective descriptive study.
Material and methods: 76 patients: 67.1% women and 32.9% men. In our cohort of patients, who underwent surgery between 2011 and 2018, we analyze the following parameters: Age, clinical and radiological suspicion, lesion size, adjuvant surgery, pathological result, reoperation, recurrences, subsequent analytical study, post-surgical complications, imaging tests performed, effectiveness, and postoperative evolution.
Results: Parathyroid lesions were correctly identified and resected in 98.68% of cases. The histological study confirmed the presence of parathyroid adenoma in 81.57%, hyperplastic tissue in 11.89%, and parathyroid cancer in 2.63% of the patients. 98.68% of the patients did not experience complications inherent to the CRG.
Conclusions: 98.68% efficacy in lesion location and treatment result.
References
Khan MA, Rafiq S, Lanitis S, Mirza FA. et al. Surgical treatment of primary hyperparathyroidism: description of techniques and advances in the field. Indian J Surg. 2014 Aug;76(4):308-15. doi: 10.1007/s12262-013-0898-0.
Santamaría I, Cannata JB. Etiopatogenia del hiperparatiroidismo primario, secundario y terciario: implicaciones de los cambios moleculares en el fracaso terapéutico. Nefrología. 2002;22(3):213-8.
Somnay YR, Weinlander E, Alfhefdi A, Schneider D. et al. Radioguided parathyroidectomy for tertiary hyperparathyroidism. J Surg Res. 2015 May 15;195(2):406-11. doi: 10.1016/j.jss.2015.02.015.
Kluijfhout WP, Vriens MR, Borel Rinkes IH, Valk GD. et al. 18F Fluorocholine PET-CT for localization of parathyroid adenomas. Ned Tijdschr Geneeskd. 2015;159:A8840.
Noureldine SI, Gooi Z, Tufano RP. Minimally invasive parathyroid surgery. Gland Surg. 2015 Oct;4(5):410-9. doi: 10.3978/j.issn.2227-684X.2015.03.07.
Suárez JP, Domínguez ML, De Santos FJ, González JM. et al. Cirugía radioguiada en el hiperparatiroidismo primario: resultados y correlación con el diagnóstico anatomopatológico intraoperatorio. Acta Otorrinolaringol Esp. Mar-Apr 2018;69(2):86-94. doi: 10.1016/j.otorri.2017.04.005.
Chen J, Zhou Q, Feng J, Wang J. Combined use of a nanocarbon suspension and 99mTc-MIBI for the intra-operative localization of the parathyroid glands. Am J Otolaryngol. Mar-Apr 2018;39(2):138-141. doi: 10.1016/j.amjoto.2017.12.008.
Dulfer RR, Franssen GJH, Hesselink DA, Hoorn EJ. et al. Systematic review of surgical and medical treatment for tertiary hyperparathyroidism. Br J Surg. 2017 Jun;104(7):804-813. doi: 10.1002/bjs.10554.
Vidya B, Chauhan S, Chandrasekhar NH, Sunil HV. et al. Radio-guided Minimally Invasive Parathyroidectomy: A Descriptive Report of the Experience from Tertiary Center in Bangalore. Indian J Nucl Med. Jul-Sep 2017;32(3):184-187. doi: 10.4103/ijnm.IJNM_9_17.
Fuentes E, López IA, Escarpanter JC, Alfonso Y. et al. Cirugía paratiroidea radioguiada: experiencia inicial. Rev Cubana Cir [Internet]. 2014;53(1)1-11. Available from: http://scielo.sld.cu/pdf/cir/v53n1/cir01114.pdf
Mehrabibahar M, Mousavi Z, Sadeghi R, Layegh P. et al. Feasibility and safety of minimally invasive radioguided parathyroidectomy using very low intraoperative dose of Tc-99m MIBI. Int J Surg. 2017 Mar;39:229-233. doi: 10.1016/j.ijsu.2017.02.009.
Domenico Rubello,Lorraine M. Fig, Dario Casara,Andrea Piotto,et al. Radioguided Surgery of Parathyroid Adenomas and Recurrent Thyroid Cancer Using the “Low Sestamibi Dose” Protocol. Cancer Biother Radiopharm. 2006 Jun;21(3):194-205. doi: 10.1089/cbr.2006.21.194.
Rubello D, Piotto A, Pagetta C, Pelizzo M, Casara D. Ectopic Parathyroid Adenomas Located at the Carotid Bifurcation.The Role of Preoperative Tc-99m MIBI Scintigraphy and the Intraoperative Gamma Probe Procedure in Surgical Treatment Planning. Clin Nucl Med. 2001 Sep;26(9):774-6. doi: 10.1097/00003072-200109000-00007.
Mayilvaganan S, Vijaya Sarathi HA, Shivaprasad C. Preoperative zoledronic acid therapy prevent hungry bone syndrome in patients with primary hyperparathyroidism. Indian J Endocrinol Metab. Jan-Feb 2017;21(1):76-79. doi: 10.4103/2230-8210.196023.
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