A Revision of Mucosal Melanoma: report of 3 clinical cases
DOI:
https://doi.org/10.34631/sporl.885Keywords:
mucosal melanoma, head and neck, case report, revisionAbstract
Objectives: To present three cases of mucosal melanoma of the head and neck. Considering the particularities and rarity of this type of tumor, to conduct a review on its characteristics, staging and treatment in Portugal.
Material and Methods: A retrospective evaluation of patients with mucosal melanomas that have been admitted in our hospital in the last two years, as well as a review of the literature.
Results: We present three patients with the diagnosis of mucosal melanoma. All (stage III patients) were submitted to primary surgical recession of the tumor. The oldest has a follow-up of >2 years, requiring surgical reintervention due to local recurrence; the most recent has 6 months of follow-up.
Conclusion: Considering the high probability of recurrence of this type of tumor, even after aggressive surgical treatment, further studies are needed to establish new therapeutic options in order to improve the prognosis of these patients.
References
- McLaughlin CC, Wu XC, Jemal A, Martin HJ, et al. Incidence of noncutaneous melanomas in the U.S. Cancer. 2005 Mar 1;103(5):1000-7. doi: 10.1002/cncr.20866.
- Patrick RJ, Fenske NA, Messina JL. Primary mucosal melanoma. J Am Acad Dermatol. 2007 May;56(5):828-34. doi: 10.1016/j.jaad.2006.06.017.
- Kuk D, Shoushtari AN, Barker CA, Panageas KS. et al (2016) Prognosis of mucosal, uveal, acral, nonacral cutaneous, and unknown primary melanoma from the time of first metastasis. Oncologist. 2016 Jul;21(7):848-54. doi: 10.1634/theoncologist.2015-0522.
– Chang AE, Karnell LH, Menck HR. The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer. 1998 Oct 15;83(8):1664-78. doi: 10.1002/(sici)1097-0142(19981015)83:8<1664::aid-cncr23>3.0.co;2-g.
- Stern SJ, Guillamondegui OM. Mucosal melanoma of the head and neck. Head Neck. Jan-Feb 1991;13(1):22-7. doi: 10.1002/hed.2880130104.
- Lee SP, Shimizu KT, Tran LM, Juillard G, Calcaterra TC. Mucosal melanoma of the head and neck: the impact of local control on survival. Laryngoscope. 1994 Feb;104(2):121-6. doi: 10.1288/00005537-199402000-00001.
- Patel SG, Prasad ML, Escrig M, Singh B et al. Primary mucosal malignant melanoma of the head and neck. Head Neck. 2002 Mar;24(3):247-57. doi: 10.1002/hed.10019.
- Meleti M, Leemans CR, de Bree R, Vescovi P. et al. Head and neck mucosal melanoma: experience with 42 patients, with emphasis on the role of postoperative radiotherapy. Head Neck. 2008 Dec;30(12):1543-51. doi: 10.1002/hed.20901.
- Lotem M, Anteby S, Peretz T, Ingber A. et al. Mucosal melanoma of the female genital tract is a multifocal disorder. Gynecol Oncol. 2003 Jan;88(1):45-50. doi: 10.1006/gyno.2002.6848.
– Tyrrell H, Payne M. Combatting mucosal melanoma: recent advances and future perspectives. Melanoma Manag. 2018 Oct 8;5(3):MMT11. doi: 10.2217/mmt-2018-0003.
- Manolidis S, Donald PJ. Malignant mucosal melanoma of the head and neck: review of the literature and report of 14 patients. Cancer. 1997 Oct 15;80(8):1373-86. doi: 10.1002/(sici)1097-0142(19971015)80:8<1373::aid-cncr3>3.0.co;2-g.
- Stárek I, Koranda P, Benes P. Sentinel lymph node biopsy: A new perspective in head and neck mucosal melanoma?. Melanoma Res. 2006 Oct;16(5):423-7. doi: 10.1097/01.cmr.0000222603.57932.b6.
- Lydiatt WM, Brandwein-Gensler M, Kraus DH, Mukherji SK. Mucosal Melanoma of the Head and Neck. In: Amin MB editor. AJCC Cancer Staging Manual 8th, New York; Springer; 2017. p. 163-169
- NCCN Clinical Practices Guidelines in Oncology – Head and Neck Cancers. Version 1.2020. Feb 2020. Avaliable from: https://www.nccn.org/professionals/physician_gls/default.aspx
- Hanna E, DeMonte F, Ibrahim S, Roberts D. et al. Endoscopic resection of sinonasal cancers with and without craniotomy: oncologic results. Arch Otolaryngol Head Neck Surg. 2009 Dec;135(12):1219-24. doi: 10.1001/archoto.2009.173.
- Temam S, Mamelle G, Marandas P, Wibault P. et al. Postoperative radiotherapy for primary mucosal melanoma of the head and neck. Cancer. 2005 Jan 15;103(2):313-9. doi: 10.1002/cncr.20775.
- Carvajal RD, Antonescu CR, Wolchok JD, Chapman PB. et al. KIT as a therapeutic target in metastatic melanoma. JAMA. 2011 Jun 8;305(22):2327-34. doi: 10.1001/jama.2011.746.
- Curtin JA, Busam K, Pinkel D, Bastian BC. Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol. 2006 Sep 10;24(26):4340-6. doi: 10.1200/JCO.2006.06.2984.
– Carvajal RD, Hamid, Ariyan C. Mucosal Melanoma. Uptodate 2020. Available from: https://www.uptodate.com/contents/mucosal-melanoma.
- Guo J, Si L, Kong Y, Flaherty KT. et al. Phase II, open-label, single-arm trial of imatinib mesylate in patients with metastatic melanoma harboring c-Kit mutation or amplification. J Clin Oncol. 2011 Jul 20;29(21):2904-9. doi: 10.1200/JCO.2010.33.9275.J
- Guo J, Carvajal RD, Dummer R, Hauschild A, et al. Efficacy and Safety of Nilotinib in Patients With KIT-Mutated Metastatic or Inoperable Melanoma: Final Results From the Global, Single-Arm, Phase II TEAM Trial. Ann Oncol. 2017 Jun 1;28(6):1380-1387. doi: 10.1093/annonc/mdx079.
- Quintás-Cardama A, Lazar AJ, Woodman SE, Kim K. et al. Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib. Nat Clin Pract Oncol. 2008 Dec;5(12):737-40. doi: 10.1038/ncponc1251.
- Moya‑Plana A, Gómez RGH, Rossoni C, Dercle L, et al. Evaluation of the efficacy of immunotherapy for non-resectable mucosal melanoma. Cancer Immunol Immunother. 2019 Jul;68(7):1171-1178. doi: 10.1007/s00262-019-02351-7.
– Sosman JA. Immunotherapy of advanced melanoma with immune checkpoint inhibition. Uptodate 2020. Available from: https://www.uptodate.com/contents/ immunotherapy-of-advanced-melanoma-with-immune-checkpoint-inhibition
- D'Angelo SP, Larkin J, Sosman JA, Lebbé C. et al. Efficacy and Safety of Nivolumab Alone or in Combination with Ipilimumab in Patients with Mucosal Melanoma: A Pooled Analysis. J Clin Oncol. 2017 Jan 10;35(2):226-235. doi: 10.1200/JCO.2016.67.9258.
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