The value of PET/CT scan for treatment response evaluation following concurrent chemoradiotherapy for patients diagnosed with locoregionally advanced head and neck squamous cell carcinoma
DOI:
https://doi.org/10.34631/sporl.878Keywords:
PET/CT, squamous cell carcinoma, neck dissection, NPVAbstract
Objectives: To define the utility of PET/CT scan for the response evaluation of patients diagnosed with locoregionally advanced HNSCC and evaluate its prognostic value.
Study Design: Retrospective study
Material and Methods: Retrospective analysis of the clinical records of patients diagnosed with HNSCC between January/2016 and June/2018 at the IPO of Coimbra, treated with concomitant CRT, who underwent a follow-up PET/CT scan. Results were compared with clinical, imagiologic and histopathological findings in the 12 months that followed treatment completion.
Results: The sample has 41 individuals. PET/CT scan achieved a 12-month nodal disease PPV and NPV of 58,3% and 91,3% respectively. A statistically significant association was found between PET/CT findings and DFS. PET/CT identified distant metastasis in 19,5% of the sample, with clear prognostic impact.
Conclusion: PET/CT is a valuable diagnostic tool for treatment response evaluation in this particular group of patients, with a high NPV for nodal disease.
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