Neoplasms of minor salivary gland - Retrospective study

Authors

  • Joana Candeias Deus Hospital Santa Maria
  • Marco Menezes Peres Hospital Prof. Doutor Fernando Fonseca
  • Ana Hebe Instituto Português de Oncologia, Lisboa Francisco Gentil
  • Lígia Ferreira Instituto Português de Oncologia, Lisboa Francisco Gentil
  • Pedro Montalvão Instituto Português de Oncologia, Lisboa Francisco Gentil
  • Miguel Magalhães Instituto Português de Oncologia, Lisboa Francisco Gentil

DOI:

https://doi.org/10.34631/sporl.629

Keywords:

malignant tumours, minor salivary gland, retrospective study

Abstract

Objectives: Descriptive analysis of cases of neoplasms of minor salivary glands treated in Otolaryngology Service Institute of Lisbon, and compares the results with what is described in the literature.

Methods: Retrospective analysis of all cases with histological diagnosis of cancer of the minor salivary glands of the nasal cavity, oral cavity, larynx and pharynx, which occurred during the period from October 1992 to November 2015, treated at the ENT service of the Portuguese Institute Oncology Lisbon Francisco Gentil.

Results: 58 cases of cancer of the minor salivary glands were documented, 60% occurred in females and 40% were male, with a mean age of 57 years. The most frequent symptom in the nasal cavity was nasal obstruction, in the oral cavity was the presence of ulcers or swelling, and oropharyngeal was pain. The most common histologic types were adenoid cystic carcinoma (33%) polymorphic adenocarcinoma (24%) and mucoepidermoid carcinoma (22%). The oropharynx was the most common location of these tumours. The surgery was the treatment of 1st line in 93% of cases and 52% had adjuvant radiotherapy. Recurrence occurred in 20% of cases. The mortality associated with the tumour was 7%.

Conclusions: Neoplasms of the minor salivary glands are rare, the most common being the adenoid cystic carcinoma, pleomorphic adenocarcinoma and mucoepidermoid carcinoma. Surgical treatment alone is effective in many cases. Mortality is related to the stage and histological type of tumour.

 

References

- Baddour HM Jr, Fedewa SA, Chen AY. Five- and 10-Year Cause-Specific Survival Rates in Carcinoma of the Minor Salivary Gland. JAMA Otolaryngol Head Neck Surg. 2016 Jan 1;142(1):67-73.

- Cummings Otolaryngology, Head and Neck Surgery 6th edition.

- Barnes L, Eveson JW, Reichart P, et al. World Health Organization Classification of Tumors. Pathology and Genetics of Head and Neck Tumors. Lyon: IARC Press; 2005. p 210.

- NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines)

- Spiro RH, Thaler HT, Hickes WF, et al. (1991) The Importance of Clinical Staging of Minor Salivary Gland Carcinoma. Am J Surg 162:330–336

- Strick J, Kelly C, Soames V, et al. Malignant tumours of the minor salivary glands: a 20 year review. Br J Plast Surg. 2004;57(7): 624-631.

- Poorten V, Hunt J, Bradley P. Recent trends in the management of minor salivary gland carcinoma. Head and Neck. 2014 Mar;36(3):444-55.

- Buchner A, Merrell PW, Carpenter WM (2007) Relative frequency of intra-oral minor salivary gland tumors: a study of 380 cases from northern California and comparison to reports from other parts of the world. J Oral Pathol Med 36(4):207–214.

- Kruse A, Grätz K, Obwegeser J, et al.Malignant minor salivary gland tumors: a retrospective study of 27 cases. Oral Maxillofac Surg (2010) 14:203–209.

- Poorten V, Balm A, Hilgers F,et al. Stage as major long term outcome predictor in minor salivary gland carcinoma. Cancer 2000;89:1195–1204.

- Guzzo M, Locati L, Prott F, et al. Major and minor salivary gland tumors. Critical Reviews in oncology/Hamatology 74 (2010) 134-148.

- Horn-Ross PL,Morrow M, Ljung BM. Diet and the risk of salivary gland cancer. Am J Epidemiol 1997;146:171-6.

- Zheng W, Shu XO, Ji BT, et al. Diet and other risk factors for cancer of the salivary glands: a population-based case-control study. Int J Cancer 1996;194-8.

- Schneider AB, Lubin J, Ron E, et al. Salivary gland tumors after childhood radiation treatment for benign conditions of the head and neck: dose–response relationships. Radiat Res 1998;149:625–30.

- Modan B, Chetrit A, Alfandary E, et al. Increased risk of salivar gland tumors after low-dose irradiation. Laryncope. 1998 Jul;108(7):1095-7.

- Dimery IW, Jones LA, Verjan RP, Raymond AK, Goepfert H, Hong WK (1987). Estrogen receptors in normal salivary gland and salivary gland carcinoma. Arch Otolaryngol Head Neck Surg 113: 1082- 1085.

- SerrainoD,BoschiniA,CarrieriP,etal.Cancerriskamongmenwith, or at risk of HIV infection in southern Europe. AIDS 2000;14:553–9.

- Dong C, Hemminki K. Second primary neoplasms among 53 159 haematolymphoproliferative malignancy patients in Sweden, 1958–1996: a search for common mechanisms. Br J Cancer 2001;85:997–1005.

- Waldron CA, el Mofty SK, Gnepp DR. Tumors of the intraoral minor salivary glands: a demographic and histologic study of 426 cases. Oral Surg Oral Med Oral Pathol 1988;66:323–333.

- Van der Wal JE, Snow GB, van der Waal I. Histological reclassification of 101 intraoral salivary gland tumors (new WHO classification). J Clin Pathol 1992;45:834–835.

- Myers EN. Tumors of Minor Salivary Gland Origin. In: Salivary Gland disorders, Springer-Verlag Berlin Heidelberg 2007:pp 323-337.

- Fujita G, Sato S, Kishino M, et al. Lymphatic vessels and related factors in adenoid cystic carcinoma of the salivary gland. Mod Pathol 2011;24: 885–891.

- Bradley PJ (2004) Adenoid Cystic Carcinoma of the Head and Neck: A Review. Curr Opin Otolaryngol Head Neck Surg 12:127–130

- Pogodzinski MS, Sabri AN, Lewis JE, Olsen KD. Retrospective study and review of polymorphous low-grade adenocarcinoma. Laryngoscope 2006;116:2145–2149.

- Terhaard CH, Lubsen H, Van der Tweel I, et al. Salivary gland carci- noma: independent prognostic factors for locoregional control, distant metastases, and overall survival: results of the Dutch head and neck on- cology cooperative group. Head Neck 2004;26:681–693.

- Zeidan Y, Pekelis L, An Y, et al. Survival benefit for adjuvant radiation therapy in minor salivary gland cancers. Oral Oncology 51 (2015) 438–445

- Rosenberg L, Weissler M, Hayes DN, et al. Concurrent chemoradiotherapy for locoregionally advanced salivary gland malignancies. Head Neck 2012;34:872–876.

- Pederson A, Salama J, Haraf D, et al. Adjuvant chemoradiotherapy for locoregionally advances and high-risk salivary gland malignancies.

- Pederson W, Haraf J, Blair A, et al. Chemoreirradiation for recurrent salivary gland malignancies. Radiother Oncol 2010;95:308–311. Head & Neck Oncology 2011, 3:31.

- Lloyd, Shane, "A Prognostic Index for Predicting Lymph Node Metastasis in Minor Salivary Gland Cancer" (2009). Yale Medicine Thesis Digital Library. Paper 89.

- Garden A, Weber S, Ang K, et al. Postoperative radiation therapy for malignant tumors of minor salivary glands: outcome and patterns of failure. Cancer 1994;73:2563-9.

- Cianchetti M, Sandow P, Scarborough L, et al. Radiation therapy for Minor Salivary Gland Carcinoma. Laryngoscope 119:July 2009.

Published

2018-05-13

How to Cite

Candeias Deus, J., Menezes Peres, M., Hebe, A., Ferreira, L., Montalvão, P., & Magalhães, M. (2018). Neoplasms of minor salivary gland - Retrospective study. Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery, 55(3), 147–153. https://doi.org/10.34631/sporl.629