Larynx carcinoma - 7 years experience in a central hospital
DOI:
https://doi.org/10.34631/sporl.657Keywords:
Larynx cancer, survival, prognostic factors, surgeryAbstract
Objectives: This study aimed to evaluate the clinical results of larynx carcinoma (CL) treatment and the prognostic factors.
Methods: It was evaluated 137 patients followed at the Otorhinolaryngology Service of the Centro Hospitalar de São João (CHSJ), with CL diagnosis, between 2004 and 2010.
Results: Patients' 5-year survival was 44.5%. Patients with a T1 carcinoma, submitted to surgery (CX), had a 5-year survival of 100%. Patients with a T4 carcinoma, submitted to CX + RT, had a 5-year survival of 39.1%. When submitted to QT+RT, 5-year survival was 13%. QT+RT treatment allowed that this patients didn’t present laryngeal dysfunction after treatment.
Conclusions: Tumor staging and therapeutic modality were prognostic factors. In selected patients, QT+RT treatment could allow satisfactory cure rates, with better functional results than surgery.
References
Ferlay J, Soertaram I, Dikshit R, Eser S et al. Cancer incidence and mortality
worldwide: sources, methods and major patterns in GLOBOCAN 2012. International Journal of Cancer. 2015;136(5):E359-86;
Gale N, Douglas R, Poljak M, Strojan P et al. Laryngeal Squamous Intraepithelial Lesions: An Updated Review on Etiology, Classification, Molecular Changes, and Treatment. Adv Anat Pathol. 2016;23(2):84-91;
Rudolph E, Dyckhoff G, Becher H, Dietz A et al. Effects of tumour stage, comorbidity and therapy on survival of laryngeal cancer patients: a systematic review and a meta-analysis. Eur Arch Otorhinolaryngol. 2011;268:165–179;
Timme D, Jonnalagadda S, Patel R, Rao K et al. Treatment Selection for T3/T4a Laryngeal Cancer: Chemoradiation Versus Primary Surgery. Annals of Otology, Rhinology & Laryngology. 2015;124(11):845-51;
Luo X , Chen L, Zhang S, Lu Z et al. Effectiveness of chemotherapy and radiotherapy for laryngeal preservation in advanced laryngeal cancer: a meta‑analysis and systematic review. Radiol Med. 2015;120(12):1153-69;
Lin C, Fedewa S, Prickett K, Kristin A et al. Comparative Effectiveness of Surgical and Nonsurgical Therapy for Advanced Laryngeal Cancer. Cancer. 2016;122(18):2845-56;
Nakata Y, Ijichi K, Hanai N, Nishikawa D et al. Treatment results of alternating chemoradiotherapy with early assessment for advanced laryngeal cancer: A multi-institutional phase II study. Auris Nasus Larynx. 2017;44(1):104-110.