Sinonasal adenocarcinomas: Experience of Lisbon Oncology Institute between 2000 and 2014
DOI:
https://doi.org/10.34631/sporl.330Keywords:
tumors, nasal, sinonasal, adenocarcinomaAbstract
Objective: To analyze treatment outcomes, including overall and disease-free survival rates, of patients with sinonasal adenocarcinomas.
Methods: Retrospective study of patients with sinonasal adenocarcinoma treated in IPOFGL between 2000 and 2014.
Results: We identified 33 patients; 17 were women and 16 men. Average age at diagnosis was 65.6 years and median follow-up was 39 months. Ethmoid sinus was the most frequent location; 51% presented at AJCC stage IV. Surgery with adjuvant radiotherapy was used in 70%. Overall survival at 36 months was 57.6%, with 40.5% disease-free survival. Recurrence was caused by local failure in majority of cases. Survival was decreased significantly in patients with sphenoid sinus involvement (p=0.038), skull base invasion (p=0.003) and recurrence metastatic disease (p<0.05).
Conclusions: Complete surgical removal with postoperative radiotherapy remains the standard treatment modality. Sphenoid sinus and skull base invasion, and development of distant metastasis portend for poor prognosis.
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