Primary mucosal malignant melanoma of the head and neck - Experience from the Portuguese Institute of Oncology in Lisbon
DOI:
https://doi.org/10.34631/sporl.595Keywords:
Mucosal malignant melanoma, nasal sinuses, oral cavityAbstract
Introduction: Mucosal melanoma of the head and neck is an uncommon disease with poor prognosis.
Material and Methods: Retrospective chart review of 32 patients treated for head and neck mucosal melanoma in a cancer center from 1998 to 2012.
Results: There were 32 cases with an average age of 70. The primary tumor was located in the nasal cavity in 24 patients and in the oral cavity in 8 patients. The majority of patients (23) underwent surgical treatment. Of these, 16 were proposed for adjunctive therapy with radiotherapy. Follow-up time ranged between 26 days to 10 years. The five year survival rate was 18%.
Conclusions: The majority of patients had an advanced stage at diagnosis and despite the treatments here was a high rate of mortality. The treatment of choice is surgery. The role of radiation therapy remains controversial.
References
Mendenhall W, Amdur R, Hinerman R, Werning J, et al. Head and Neck Mucosal Melanoma. Am Jounal Clin Oncol Dez 2005 28:626-629
National Comprehensive Cancer Network. Head and Neck Cancers, Version I.2012
Seetharamu N, OTT A, Pavlick A, Mucosal Melanomas: A case-based review of the literature. Oncologist Jul 2010; 15(7):772-781
Moreno, A., Roberts B., Kupferman E., DeMonte F., et al. Mucosal melanoma of the nose and paranasal sinuses, a contemporary experience from the M. D. Anderson Cancer Center. Cancer, Maio 2010 116: 2215–2223.
Cid O. Primary mucosal malignant melanoma of the head and neck, a Review of 29 cases. Skin Cancer. 2003;18:83-90
Manolidis, Spiros, and Paul J. Donald. “Malignant mucosal melanoma of the head and neck.” Cancer 80.8 (2000): 1373-1386.
Medina E., Ferlito A., Pellitteri K., Shaha R., et al. Current management of mucosal melanoma of the head and neck. Journal of surgical oncology, 2006 83(2), 116-122.
Chan L., Chan W. e Wei I. Mucosal melanoma of the head and neck: 32-year experience in a tertiary referral hospital. The Laryngoscope, Dez 2012 122: 2749–2753.
Penel N., Mallet Y., Mirabel X., Van T., et al. Primary mucosal melanoma of head and neck: prognostic value of clear margins. The Laryngoscope, 2006, 116(6), 993-995.
Jethanamest D., Vila P., Sikora A., Morris T. Predictors of Survival in Mucosal melanoma of the Head and Neck. Annals of Surgical Oncology Out 2011, Volume 18, Issue 10, pp 2748-2756.
Prasad L., Patel G., Huvos G., Shah P., et al. Primary mucosal melanoma of the head and neck. Câncer (2004)., 100(8), 1657-1664.
