Retrospective diagnosis of congenital cytomegalovirus infection in a cohort of children with neurosensorial hearing impairment
DOI:
https://doi.org/10.34631/sporl.437Keywords:
Child deafness, cytomegalovirus infection, Guthrie cardsAbstract
Objectives: To determine the prevalence of congenital cytomegalovirus (CMV) infection as a cause of hearing impairment in children.
Methods: We conducted a retrospective cohort study based on patient clinical records. Children were selected if they had moderate (or worse) bilateral sensorioneural hearing loss, with no established diagnosis. Data blood storage cards kept in a reference laboratory in Portugal were analyzed with a heatinduced deoxyribonucleic acid (DNA) extraction technique, followed by polymerase chain reaction to amplify CMV DNA.
Results: Of 83 tested cards, 8 (9,6%) were positive. In our cohort, eleven patients have confirmed congenital CMV infection, accounting for 8,1% of cases with an established diagnosis, but only 3,4% of cases overall.
Conclusion: Congenital CMV infection is a significant cause of hearing impairment in children from our study population. Retrospective diagnosis can be made through data blood storage cards analysis.
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