Laryngeal hematoma caused by persistent cough in patient with hemophilia A – Case report
DOI:
https://doi.org/10.34631/sporl.123Keywords:
Laryngeal hematoma, hemophilia A, persistent cough, conservative managementAbstract
The laryngeal hematoma is a rare event in patients with hemophilia A that may compromise the airway and is usually associated with persistent cough as a result of a respiratory infection. If there is clinical stability, the treatment of the relying cause, the cough abolition, the reposition of the clotting factors and a tight surveillance are enough for the disappearing of the hematoma and normalization of the airway, without need of intubation or surgical procedure. The authors present a case report of a patient with factor VIII deficiency and with factor VIII inhibitors treated with a conservative management with progressive resolution of the symptoms.
References
Kempton CL, Escobar MA, Roberts HR. Hemophilia Care in The 21st Century. Clin Adv Hematol Oncol. 2004 Nov;2(11):733-40.
Beutler E, ed. Williams Hematology. 6th ed. New York: McGraw Hill; 2001:1639-1658.
Chaves DG, Rodrigues CV. Desenvolvimento de inibidores do fator VIII na hemofilia A. Ver Bras Hematol Hemoter. 2009 Sep; 31(5):384-390.
Ehrenforth S, Kreuz W, Scharrer I, et al. Incidence of development of factor VIII and factor IX inhibitors in haemophiliacs. Lancet. 1992;339:594-598.
Abshire T, Kenet G. Recombinant factor VIIa: review of efficacy, dosing regimens and safety in patients with congenital and acquired factor VIII or IX inhibitors. J Thromb Haemost. 2004 Jun;2:899-909.
Kerr HD, Kwaselow A. Vocal cord hematomas complicating anticoagulant therapy. Ann Emerg Me. 1984 Jul;13(7):552-3.
Hirshoren N, Varon D, Weinberger JM, Gross M. Airway obstruction and hemophilia A: epiglottis hematoma. Laryngoscope. 2010 Jul;120(7):1428-9.
Becton DL, Hockenberry MJ, Kinney TR. Isolated vocal cord hematoma in a child with severe factor VIII deficiency. South Med J. 1987 Feb; 80(2):271-2.
Kiviranta UK. Laryngeal haematomas due to coagulopathies. J Laryngol Otol. 1967 May;81(5):503.
Colman BH. Haemophilia envolving the pharynx and larynx. J Laryngol Otol.2007 Jun;70(9):540-543.
