Positive predictive value for malignancy in biopsies in head and neck in the outpatient clinic - Series of 365 cases
DOI:
https://doi.org/10.34631/sporl.828Keywords:
Head and neck cancer, biopsy, HPV, p16, EBVAbstract
Objectives: To determine the positive predictive value (PPV) for malignancy and distribution of head and neck cancer diagnosed by biopsy in the outpatient clinic of a tertiary hospital. To identify the presence of Epstein-Barr virus (EBV) and human papilloma virus (HPV) in nasopharyngeal and oropharyngeal carcinoma, respectively.
Materials and Methods: Observational, retrospective, transversal study of the pathologic anatomy results of 365 biopsies performed on the Otorhinolaryngology outpatient clinic for clinical/imagological suspected malignancy in a 2 year period (2018-2019). The PPV for malignancy was calculated for each anatomical region.
Results: We identified 111 malignant results (PPV 30,4%), of which 81% were squamous cell carcinoma (SCC). Immunohistochemistry stained positive for EBV in 75% of nonkeratinizing SCC of the nasopharynx and for p16 (HPV) in 9,7% of the SCC of the oropharynx.
Conclusion: The most common diagnosis in the malignant results was SCC. There was a low HPV incidence in oropharynx SCC.
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