Complications after total laryngectomy - Risk factors and perioperative approach to the patient

Authors

  • Sónia Martins Serviço de Otorrinolaringologia do Centro Hospitalar Universitário de São João, Departamento de Cirurgia e Fisiologia da Faculdade de Medicina da Universidade do Porto, Portugal
  • Helena Silveira Serviço de Otorrinolaringologia do Centro Hospitalar Universitário de São João, Departamento de Cirurgia e Fisiologia da Faculdade de Medicina da Universidade do Porto, Portugal
  • Mafalda Sousa Serviço de Otorrinolaringologia do Centro Hospitalar Universitário de São João, Departamento de Cirurgia e Fisiologia da Faculdade de Medicina da Universidade do Porto, Portugal
  • Margarida Santos Serviço de Otorrinolaringologia do Centro Hospitalar Universitário de São João, Porto Portugal
  • Ricardo P. Vaz Serviço de Otorrinolaringologia do Centro Hospitalar Universitário de São João, Unidade de Anatomia - Departamento de Biomedicina da Faculdade de Medicina da Universidade do Porto, Center for Health Technology and Services Research (CINTESIS), Porto, Portugal

DOI:

https://doi.org/10.34631/sporl.819

Keywords:

total laryngectomy, nutrition, pharyngocutaneous fistula.

Abstract

Objectives: To investigate the potential association between characteristics of patients submitted to total laryngectomy (TL) and postoperative complications. To outline perioperative strategies in order to prevent complications. 

Material and methods: Retrospective study that included 57 patients operated for larynx/pharynx epidermoid carcinoma between 2007 and 2019. Evaluated parameters included laryngectomized patient’s nutritional status, surgical factors, and neoplasm characteristics. 

Results: The overall postoperative complications rate was 43.8%: pharyngocutaneous fistula (19.3%), cervical abscess (17.5%) and seroma/hematoma (7%). The duration of hospital stays increased significantly (p<0.001) with postoperative complications and there was a significant association between higher leucocyte values and the development of complications (p=0.025). All patients presenting BMI< 20kg/m2 and albumin< 35g/L had pharyngocutaneous fistula. 

Conclusions: Post laryngectomy complications increase significantly the length of hospital stay. A multidisciplinary approach is crucial to reduce the rate of these situations. 

References

Forastiere AA, Ismaila N, Lewin JS, Nathan CA, et al. Use of Larynx-Preservation Strategies in the Treatment of Laryngeal Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update. J Clin Oncol. 2018 Apr 10;36(11):1143-1169. doi: 10.1200/JCO.2017.75.7385.

Dyckhoff G, Plinkert PK, Ramroth H. A change in the study evaluation paradigm reveals that larynx preservation compromises survival in T4 laryngeal cancer patients. BMC Cancer. 2017 Sep 1;17(1):609. doi: 10.1186/s12885-017-3608-7.

Thompson CSG, Asimakopoulos P, Evans A, Vernham G, et al. Complications and predisposing factors from a decade of total laryngectomy. J Laryngol Otol. 2020 Mar;134(3):256-262. doi: 10.1017/S0022215120000341.

Sayles M, Grant DG. Preventing pharyngo-cutaneous fistula in total laryngectomy: a systematic review and meta-analysis. Laryngoscope. 2014 May;124(5):1150-63. doi: 10.1002/lary.24448.

Caburet C, Farigon N, Mulliez A, Mom T. et al. Impact of nutritional status at the outset of assessment on postoperative complications in head and neck cancer. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Dec 20;S1879-7296(19)30208-X. doi: 10.1016/j.anorl.2019.12.005.

Goepfert RP, Hutcheson KA, Lewin JS, Desai NG, et al. Complications, hospital length of stay, and readmission after total laryngectomy. Cancer. 2017 May 15;123(10):1760-1767. doi: 10.1002/cncr.30483.

Helman SN, Brant JA, Kadakia SK, Newman JG. et al. Factors associated with complications in total laryngectomy without microvascular reconstruction. Head Neck. 2018 Nov;40(11):2409-2415. doi: 10.1002/hed.25363.

Schwartz SR, Yueh B, Maynard C, Daley J. et al. Predictors of wound complications after laryngectomy: A study of over 2000 patients. Otolaryngol Head Neck Surg. 2004 Jul;131(1):61-8. doi: 10.1016/j.otohns.2003.08.028.

Danan D, Shonka DCJ, Selman Y, Chow Z. et al. Prognostic value of albumin in patients with head and neck cancer. Laryngoscope. 2016 Jul;126(7):1567-71. doi: 10.1002/lary.25877.

Son HJ, Roh JL, Choi SH, Nam SY. et al. Nutritional and hematologic markers as predictors of risk of surgical site infection in patients with head and neck cancer undergoing major oncologic surgery. Head Neck. 2018 Mar;40(3):596-604. doi: 10.1002/hed.25031.

Le Flem M, Santini L, Boulze C, Alshukry A. et al. Early oral hydration protects against pharyngocutaneous fistula after total laryngectomy or total pharyngolaryngectomy. Head Neck. 2020 Mar 3. doi: 10.1002/hed.26122.

Kuboki A, Kanaya H, Nakayama T, Konno W et al. Prognostic value of C-reactive protein/albumin ratio for patients with hypopharyngeal and laryngeal cancer undergoing invasive surgery involving laryngectomy. Head Neck. 2019 May;41(5):1342-1350. doi: 10.1002/hed.25565.

Maggini S, Wintergerst ES, Beveridge S, Hornig DH. Selected vitamins and trace elements support immune function by strengthening epithelial barriers and cellular and humoral immune responses. Br J Nutr. 2007 Oct;98 Suppl 1:S29-35. doi: 10.1017/S0007114507832971.

Gill A, Farwell DG, Moore MG. Nutrition and Perioperative Care for the Patient with Head and Neck Cancer. Oral Maxillofac Surg Clin North Am. 2018 Nov;30(4):411-420. doi: 10.1016/j.coms.2018.06.003.

Bril SI, Pezier TF, Tijink BM, Janssen LM. et al. Preoperative low skeletal muscle mass as a risk factor for pharyngocutaneous fistula and decreased overall survival in patients undergoing total laryngectomy. Head Neck. 2019 Jun;41(6):1745-1755. doi: 10.1002/hed.25638.

Leistra E, Eerenstein SE, van Aken LH, Jansen F. et al. Effect of Early Individualized Dietary Counseling on Weight Loss, Complications, and Length of Hospital Stay in Patients With Head and Neck Cancer: A Comparative Study. Nutr Cancer. 2015;67(7):1093-103. doi: 10.1080/01635581.2015.1073755.

Talwar B, Donnelly R, Skelly R, Donaldson M. Nutritional management in head and neck cancer: United Kingdom National Multidisciplinary Guidelines. J Laryngol Otol. 2016 May;130(S2):S32-S40. doi: 10.1017/S0022215116000402.

Nutrition Support for Adults: Oral Nutrition Support, Enteral Tube Feeding and Parenteral Nutrition. London: National Collaborating Centre for Acute Care (UK); 2006.

Yanni A, Dequanter D, Lechien JR, Loeb I. et al. Malnutrition in head and neck cancer patients: Impacts and indications of a prophylactic percutaneous endoscopic gastrostomy. Eur Ann Otorhinolaryngol Head Neck Dis. 2019 Jun;136(3S):S27-S33. doi: 10.1016/j.anorl.2019.01.001.

Rowell NP. Tumor implantation following percutaneous endoscopic gastrostomy insertion for head and neck and oesophageal cancer: Review of the literature. Head Neck. 2019 Jun;41(6):2007-2015. doi: 10.1002/hed.25652.

Ahmed OH, Roden DF, Ahmed YC, Wang B. et al. Perioperative Management of Total Laryngectomy Patients: A Survey of American Head and Neck Society Surgeons. Ann Otol Rhinol Laryngol. 2019 Jun;128(6):534-540. doi: 10.1177/0003489419830118.

Published

2020-12-05

How to Cite

Martins, S., Silveira, H., Sousa, M., Santos, M., & Vaz, R. P. (2020). Complications after total laryngectomy - Risk factors and perioperative approach to the patient. Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery, 58(4), 173–179. https://doi.org/10.34631/sporl.819

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Section

Original Article