ENT manifestation in children with Eosinophilic Esophagitis
DOI:
https://doi.org/10.34631/sporl.832Keywords:
Eosinophilic esophagitis, Otolaryngology, allergic rhinitis, childAbstract
Objective: Characterize a population of children with Eosinophilic Esophagitis (EoE), highlighting their symptoms, ENT physical examination and previous medical history.
Material and Methods: Cross-sectional observational study of children aged 6 to 17 years, diagnosed with EoE, until January 2019. A clinical observation protocol was applied to every child.
Results: Fifteen children were included. The majority had nasal symptoms (93,3%) and/or pharyngolaryngeal symptoms (80%). Ear complaints were present in 40% of the children. The majority were submitted to flexible nasal endoscopy (73,3%) and 33,3% had indirect signs of laryngopharyngeal reflux. Before this study, 40% of the children had already been observed by an ENT doctor. Atopy was present in 80% of the children.
Conclusions: The ENT’s role in the management of children with EoE may be to consider this diagnosis, to treat ENT manifestations and to identify patients with atopy and laryngopharyngeal reflux who need management by other specialities.
References
Lucendo AJ, Molina-Infante J, Arias Á, von Arnim U. et al. Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults. United European Gastroenterol J. 2017 Apr;5(3):335-358. doi: 10.1177/2050640616689525.
Attwood SE, Smyrk TC, Demeester TR, Jones JB. Esophageal eosinophilia with dysphagia. A distinct clinicopathologic syndrome. Dig Dis Sci. 1993 Jan;38(1):109-16. doi: 10.1007/BF01296781.
Straumann A, Spichtin HP, Bernoulli R, Loosli J, et al. Idiopathic eosinophilic esophagitis: a frequently overlooked disease with typical clinical aspects and discrete endoscopic findings. Schweiz Med Wochenschr. 1994 Aug 20;124(33):1419-29.
Straumann A, Schoepfer A. Update on basic and clinical aspects of eosinophilic oesophagitis. Gut. 2014 Aug;63(8):1355-63. doi: 10.1136/gutjnl-2013-306414.
Soon IS, Butzner JD, Kaplan GG, deBruyn JC. Incidence and prevalence of eosinophilic esophagitis in children. J Pediatr Gastroenterol Nutr. 2013 Jul;57(1):72-80. doi: 10.1097/MPG.0b013e318291fee2.
Arias Á, Pérez-Martínez I, Tenías JM, Lucendo AJ. Systematic review with meta-analysis: the incidence and prevalence of eosinophilic oesophagitis in children and adults in population-based studies. Aliment Pharmacol Ther. 2016 Jan;43(1):3-15. doi: 10.1111/apt.13441.
González-Cervera J, Arias Á, Redondo-González O, Cano-Mollinedo MM. et al. Association between atopic manifestations and eosinophilic esophagitis: A systematic review and meta-analysis. Ann Allergy Asthma Immunol. 2017 May;118(5):582-590.e2. doi: 10.1016/j.anai.2017.02.006
Karkos PD, Srivastava R, Kaptanis S, Vaughan C. Eosinophilic esophagitis for the otolaryngologist. Int J Otolaryngol. 2012;2012:181402. doi: 10.1155/2012/181402.
Kelly EA, Linn D, Keppel KL, Noel RJ. et al Otolaryngologic surgeries are frequent in children with eosinophilic esophagitis. Ann Otol Rhinol Laryngol. 2015 May;124(5):355-60. doi: 10.1177/0003489414558108.
Górriz-Gil C, Villarreal IM, Álvarez-Montero Ó, Rodríguez-Valiente A. et al. Eosinophilic esophagitis: A relevant entity for the otolaryngologist. Acta Otorrinolaringol Esp. May-Jun 2016;67(3):167-78. doi: 10.1016/j.otorri.2015.06.002.
Kubik M, Thottam P, Shaffer A, Choi S. The role of the otolaryngologist in the evaluation and diagnosis of eosinophilic esophagitis. Laryngoscope. 2017 Jun;127(6):1459-1464. doi: 10.1002/lary.26373.
Otteson TD, Mantle BA, Casselbrant ML, Goyal A. The otolaryngologic manifestations in children with eosinophilic esophagitis. Int J Pediatr Otorhinolaryngol. 2012 Jan;76(1):116-9. doi: 10.1016/j.ijporl.2011.10.015.
De Matteis A, Pagliaro G, Corleto VD, Pacchiarotti C. et al. Eosinophilic Esophagitis in Children: Clinical Findings and Diagnostic Approach. Curr Pediatr Rev. 2019 Oct 4. doi: 10.2174/1573396315666191004110549.
Stinnett S, Dhillon V, Akst L. Laryngopharyngeal Reflux: Current Concepts on Etiology and Pathophysiology and Its Role in Dysphagia. Current Otorhinolaryngology Reports. 2018; 6(2): 196-202. doi: 10.1007/s40136-018-0192-6.
Gomez Torrijos E, Gonzalez-Mendiola R, Alvarado M, Avila R. et al. Eosinophilic Esophagitis: Review and Update. Front Med (Lausanne). 2018 Oct 9;5:247. doi: 10.3389/fmed.2018.00247.
Vavricka SR, Storck CA, Wildi SM, Tutuian R. et al. Limited diagnostic value of laryngopharyngeal lesions in patients with gastroesophageal reflux during routine upper gastrointestinal endoscopy. Am J Gastroenterol. 2007 Apr;102(4):716-22. doi: 10.1111/j.1572-0241.2007.01145.x.
Lima-Rodrigues M, Valle-Fernandes A, Lamas N, Cruz A. et al. A new model of laryngitis: neuropeptide, cyclooxygenase, and cytokine profile. Laryngoscope. 2008 Jan;118(1):78-86. doi: 10.1097/MLG.0b013e3181492400.
Wise SK, Lin SY, Toskala E, Orlandi RR. et al. International Consensus Statement on Allergy and Rhinology: Allergic Rhinitis. Int Forum Allergy Rhinol. 2018 Feb;8(2):108-352. doi: 10.1002/alr.22073.
Koster ES, Raaijmakers JA, Vijverberg SJ, van der Ent CK. et al. Asthma symptoms in pediatric patients: differences throughout the seasons. J Asthma. 2011 Sep;48(7):694-700. doi: 10.3109/02770903.2011.601780.
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