Giant cell tumor in the anterior cranial fossa – case report and systematic review
DOI:
https://doi.org/10.34631/sporl.2204Keywords:
giant cell tumor, skull base, anterior cranial fossa, cribriform plateAbstract
Objectives: literature review on giant cell tumors of the bone (GCTB) involving the anterior skull base and case report of endoscopic endonasal surgical treatment.
Study Design: qualitative systematic review.
Materials and Methods: PubMed, BMC and Cochrane Library database review, based on the PRISMA MODEL. Iconographic description with images of the transcribriform endoscopic approach.
Results: 36 articles were selected and 21 GCTB involving the anterior skull base were identified. We present a case of TCGO centered on the cribriform plate, which underwent complete endoscopic endonasal excision at our institution.
Conclusion: according to the literature review, sinunasal GCTO with involvement of the anterior skull base are extremely rare, being this the second described originating from the cribriform plate. Although benign, it presented with aggressive behavior and complete surgical excision using and endonasal approach was carried out without complications.
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Noël G, Ben Jelloun H, Feuvret L, Calugaru V, Mazeron JJ, Habrand JL. Les tumeurs à cellules géantes de la base du crâne : revue de la littérature à partir de deux cas. Cancer Radiother. 2006 Jun;10(4):175-84. doi: 10.1016/j.canrad.2006.05.008.
Sharma RR, Mahapatra AK, Pawar SJ, Sousa J, Dev EJ. Craniospinal giant cell tumors: clinicoradiological analysis in a series of 11 cases. J Clin Neurosci. 2002 Jan;9(1):41-50. doi: 10.1054/jocn.2001.0963.
Yaprak Bayrak B, Özcan E, Vural Ç, Emengen A, Çabuk B, Ceylan S. A single-center experience with giant cell tumors of sphenoid bone and clivus. Tumori. 2021 Dec;107(6):NP94-NP100. doi: 10.1177/03008916211024357.
Bardakhchyan S, Kager L, Danielyan S, Avagyan A, Karamyan N, Vardevanyan H. et al. Denosumab treatment for progressive skull base giant cell tumor of bone in a 14 year old female – a case report and literature review. Ital J Pediatr. 2017 Mar 29;43(1):32. doi: 10.1186/s13052-017-0353-0.
Hug EB, Muenter MW, Adams JA, De Vries A, Rosenberg AE, Munzenrider JE. 3-D-conformal radiation therapy for pediatric giant cell tumors of the skull base. Strahlenther Onkol. 2002 May;178(5):239-44. doi: 10.1007/s00066-002-0931-x.
Larson AK, Amjad EH, RAulicino M. A rare giant cell lesion originating from the nasal septum. Ann Clin Case Stud. 2018; 1(1):1002.
Singh S, Mankotia DS, Shankar KB, Siraj F. A rare tumor of clivus masquerading as pituitary adenoma. Asian J Neurosurg. 2020 Dec 21;15(4):1091-1095. doi: 10.4103/ajns.AJNS_188_20.
Handler SD, Savino PJ, Peyster RG, Schatz NJ. Giant cell tumor of the ethmoid sinus: an unusual cause of proptosis in a child. Otolaryngol Head Neck Surg. 1982 Jul-Aug;90(4):513-5. doi: 10.1177/019459988209000430.
Liu S, Tang R, Mao S, Zhang W. Clinical outcomes of coblation-assisted pediatric endoscopic endonasal skull base surgery. Int J Pediatr Otorhinolaryngol. 2022 May:156:111089. doi: 10.1016/j.ijporl.2022.111089.
Huh A, Villelli N, Martinez D, Ting J, Birhiray R, Payner TD. et al. Denosumab treatment for a residual giant cell tumor of the clivus: a case report and review of the literature. World Neurosurg. 2018 Oct:118:98-101. doi: 10.1016/j.wneu.2018.06.242.
Zhang Z, Xu J, Yao Y, Chu S, Cheng H, Chen D. et al. Giant cell tumors of the skull: a series of 18 cases and review of the literature. J Neurooncol. 2013 Dec;115(3):437-44. doi: 10.1007/s11060-013-1242-z.
Sekar A, Rudrappa S, Gopal S, Ghosal N, Gupta V, Ts L. Preoperative cytoreduction of clival giant cell tumor: an effective replication of the systemic modality in the skull base. World Neurosurg. 2018 Nov:119:97-102. doi: 10.1016/j.wneu.2018.07.207.
Biswas R, Halder A. A rare case report of giant cell tumor of the sphenoid bone in a patient who developed “erythema multiforme associated with phenytoin and cranial radiation therapy syndrome”. Asian J Neurosurg. 2018 Jul-Sep;13(3):877-880. doi: 10.4103/ajns.AJNS_352_16.
Zhao J, Qian T, Zhi Z, Li Q, Kang L, Wang J. et al. Giant cell tumor of the clivus: A case report and review of the literature. Oncol Lett. 2014 Dec;8(6):2782-2786. doi: 10.3892/ol.2014.2528.
Company MM, Ramos R. Giant cell tumor of the sphenoid. Arch Neurol. 2009 Jan;66(1):134-5. doi: 10.1001/archneurol.2008.509.
Pousti BT, Andera L, Haugen TW. Sphenoid sinus giant cell tumor: a case report and literature review. ORL J Otorhinolaryngol Relat Spec. 2020;82(3):168-174. doi: 10.1159/000506207.
Zorlu F, Selek U, Soylemezoglu F, Oge K. Malignant giant cell tumor of the skull base originating from clivus and sphenoid bone. J Neurooncol. 2006 Jan;76(2):149-52. doi: 10.1007/s11060-005-4343-5.
Yildirim AE, Divanlioglu D, Cetinalp NE, Ozhamam E, Belen AD. Endoscopic endonasal treatment of a large clival giant cell tumor invading the cavernous sinus and temporal lobe. J Craniofac Surg. 2014 Mar;25(2):446-8. doi: 10.1097/SCS.0000000000000485
Iacoangeli M, Di Rienzo A, Re M, Alvaro L, Nocchi N, Gladi M. et al. Endoscopic endonasal approach for the treatment of a large clival giant cell tumor complicated by an intraoperative internal carotid artery rupture. Cancer Manag Res. 2013:5:21-4. doi: 10.2147/CMAR.S38768
Goto Y, Furuno Y, Kawabe T, Ohwada K, Tatsuzawa K, Sasajima H. et al. Treatment of a skull-base giant cell tumor with endoscopic endonasal resection and denosumab: case report. J Neurosurg. 2017 Feb;126(2):431-434. doi: 10.3171/2016.3.JNS152802.
Sasagawa Y, Tachibana O, Shiraga S, Takata H, Kinoshita E, Nojima T. et al. Secondary malignant giant cell tumor of the clivus: Case report. Clin Neurol Neurosurg. 2012 Jul;114(6):786-8. doi: 10.1016/j.clineuro.2011.12.041.
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