Vocal Cord Leukoplakia: Malignant Predictor?
DOI:
https://doi.org/10.34631/sporl.993Keywords:
leukoplakia, malignancy, predictiveAbstract
The aim of this study was to analyze clinical and anatomopathological factors and their relationship with recurrence or malignancy in patients with vocal cords leukoplakia. A retrospective analysis of the clinical files of patients undergoing laryngeal microsurgery for excision of leukoplakia from vocal cords was performed between 2017 and 2019. The study sample consisted of 56 patients, 54 male and 2 female, with a mean age of 61.6 ± 6.9 years-old. The degree of dysplasia and the extent of leukoplakia revealed statistically significant differences (p < 0.05) in the Fisher test and the X2 test in both the risk of malignancy and the risk of recurrence after surgery. There were no other statistically significant differences to report. These results suggest that the extent of leukoplakia and the degree of dysplasia could be predictive factors for the risk of malignancy and recurrence.
References
- Frangez I, Gale N, Luzar B. The interpretation of leukoplakia in laryngeal pathology. Acta Otolaryngol Suppl. 1997;527:142-4. doi: 10.3109/00016489709124058.
- Friedmann I. Precancerous lesions of the larynx. Can J Otolaryngol. 1974;3(4):528-32.
- Bouquot JE, Gnepp DR. Laryngeal precancer: a review of the literature, commentary, and comparison with oral leukoplakia. Head Neck. Nov-Dec 1991;13(6):488-97. doi: 10.1002/hed.2880130604.
- Ricci G, Molini E, Faralli M, Simoncelli C. Retrospective study on precancerous laryngeal lesions: long-term follow-up. Acta Otorhinolaryngol Ital. 2003 Oct;23(5):362-7.
- van Hulst AM, Kroon W, van der Linden ES, Nagtzaam L, Ottenhof SR, Wegner I. et al. Grade of dysplasia and malignant transformation in adults with premalignant laryngeal lesions. Head Neck. 2016 Apr;38 Suppl 1:E2284-90. doi: 10.1002/hed.24185.
- Stanikova L, Satankova J, Kucova H, Walderova R, Zelenik K, Kominek P. The role of narrow-band imaging (NBI) endoscopy in optical biopsy of vocal cord leukoplakia. Eur Arch Otorhinolaryngol. 2017 Jan;274(1):355-359. doi: 10.1007/s00405-016-4244-6.
- Shoffel-Havakuk H, Lahav Y, Meidan B, Haimovich Y, Warman M, Hain M. et al. Does narrow band imaging improve preoperative detection of glottic malignancy? A matched comparison study. Laryngoscope. 2017 Apr;127(4):894-899. doi: 10.1002/lary.26263.
- Young CK, Lin WN, Lee LY, Lee LA, Hsin LJ, Liao CT. et al. Laryngoscopic characteristics in vocal leukoplakia: inter-rater reliability and correlation with histology grading. Laryngoscope. 2015 Feb;125(2):E62-6. doi: 10.1002/lary.24884.
- Lee DH, Yoon TM, Lee JK, Lim SC. Predictive factors of recurrence and malignant transformation in vocal cord leukoplakia. Eur Arch Otorhinolaryngol. 2015 Jul;272(7):1719-24. doi: 10.1007/s00405-015-3587-8.
- Kambic V. Epithelial hyperplastic lesions–a challenging topic in laryngology. Acta Otolaryngol Suppl. 1997;527:7-11.
- Bartlett RS, Heckman WW, Isenberg J, Thibeault SL, Dailey SH. Genetic characterization of vocal fold lesions: leukoplakia and carcinoma. Laryngoscope. 2012 Feb;122(2):336-42. doi: 10.1002/lary.22417.
- Chen M, Cheng L, Li CJ, Chen J, Shu YL, Wu HT. Nonsurgical Treatment for Vocal Fold Leukoplakia: An Analysis of 178 Cases. Biomed Res Int. 2017;2017:6958250. doi: 10.1155/2017/6958250.
- Thompson L. World Health Organization classification of tumours: pathology and genetics of head and neck tumours. Ear Nose Throat J. 2006 Feb;85(2):74.
- Talamini R, Bosetti C, La Vecchia C, Dal Maso L, Levi F, Bidoli E. et al. Combined effect of tobacco and alcohol on laryngeal cancer risk: a case-control study. Cancer Causes Control. 2002 Dec;13(10):957-64. doi: 10.1023/a:1021944123914.
- Chen M, Li C, Yang Y, Cheng L, Wu H. A morphological classification for vocal fold leukoplakia, Braz J Otorhinolaryngol. Sep-Oct 2019;85(5):588-596. doi: 10.1016/j.bjorl.2018.04.014.
- Weller MD, Nankivell PC, McConkey C, Paleri V, Mehanna HM. The risk and interval to malignancy of patients with laryngeal dysplasia; a systematic review of case series and meta-analysis. Clin Otolaryngol. 2010 Oct;35(5):364-72. doi: 10.1111/j.1749-4486.2010.02181.x.
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