Auditory Brainstem Response in Neonatal Hyperbilirubinemia
DOI:
https://doi.org/10.34631/sporl.974Keywords:
hyperbilirubinemia, bilirubin, neonatal, brainstem auditory evoked potentials, childhood hearing lossAbstract
Objective: To establish the changes in auditory brainstem responses (ABR) associated to neonatal hyperbilirubinemia in term infants.
Study design: Retrospective study.
Material & Methods: The clinical records of 27 children born in Hospital Prof. Doutor Fernando Fonseca, who underwent ABR before 12 months of life, were reviewed. The ABR results were compared between the group of infants with hyperbilirubinemia (Group A) and the group without hyperbilirubinemia (Group B).
Results: The interval I-V was longer in Group A (n=24 ears), compared to Group B (n=30 ears), p=0,46. There was no statistical difference in latency of peaks I, III or V, neither in intervals I-III or III-V (p>0,05) between groups, although they tend to be longer in group A. The limit of 20 mg/dl of total bilirubin was not related to significant differences in ABR parameters.
Conclusions: Neonatal hyperbilirubinemia was associated to an increase in ABR measurements, which might traduce toxicity to the auditory pathway, even with bilirubin levels lower than 20 mg/dl.
References
O’Neill A, Coutinho M, Monteiro L. Audiologia, som e audição - Das bases à clínica. 1a ed. Luísa M, Subtil J, editors. Queluz: Círculo Médico; 2018.
Year 2019 position statement: principles and guidelines for early hearing detection and intervention programs. Joint Committee on Infant Hearing. J Early Hear Detect Interv [Internet]. 2019;4(2):1–44. doi:10.15142/fptk-b748 Available from: https://digitalcommons.usu.edu/jehdi/vol4/iss2/1/
Ambalavanan N, Carlo W. Jaundice and Hyperbilirubinemia in the Newborn. In: Liegman RK, Stanon BE, Geme JW, Schor NF, editors. Nelson textbook of pediatrics. 20th ed. Philadelphia: Elsevier; 2015. p. 871–5.
Akinpelu OV, Waissbluth S, Daniel SJ. Auditory risk of hyperbilirubinemia in term newborns: a systematic review. Int J Pediatr Otorhinolaryngol. 2013 Jun;77(6):898-905. doi: 10.1016/j.ijporl.2013.03.029.
Olds C, Oghalai JS. Audiologic impairment associated with bilirubin-induced neurologic damage. Semin Fetal Neonatal Med. 2015 Feb;20(1):42-46. doi: 10.1016/j.siny.2014.12.006
Teixeira MH, Borges VMS, Riesgo RDS, Sleifer P. Hyperbilirubinemia impact on newborn hearing: a literature review. Rev Assoc Med Bras (1992). 2020 Jul;66(7):1002-1008. doi: 10.1590/1806-9282.66.7.1002
Ezzeldin ZM, Sharaf E, Hamdy HS, Abdelwahab Selim YA. Hearing screening in neonates with hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2021 Mar;142:110591. doi: 10.1016/j.ijporl.2020.110591.
Xu J, Weng M, Li N, Wu X, Gao L, Yao H, et al. Relationship research between auditory neuropathy spectrum disorder and exchange transfusion in neonates with severe hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2019 Aug;123:146-150. doi: 10.1016/j.ijporl.2019.04.044.
Mandour YM, El Sayed MA, El Sayed Morgan A, Bassam R, Fadl H, Elrefae A. Audiological assessment of neonatal hyperbilirubinemia. Int J Pediatr Otorhinolaryngol. 2020 Aug;135:110126. doi: 10.1016/j.ijporl.2020.110126.
Corujo-Santana C, Falcón-González JC, Borkoski-Barreiro SA, Pérez-Plasencia D, Ramos-Macías Á. The relationship between neonatal hyperbilirubinemia and sensorineural hearing loss. Acta Otorrinolaringol Esp. Nov-Dec 2015;66(6):326-31. doi: 10.1016/j.otorri.2014.10.001.
Sharma P, Chhangani NP, Meena KR, Jora R, Sharma N, Gupta BD. Brainstem evoked response audiometry (BAER) in neonates with hyperbilirubinemia. Indian J Pediatr. 2006 May;73(5):413-6. doi: 10.1007/BF02758564.
Salehi N, Bagheri F, Ramezani Farkhani H. Effects of hyperbilirubinemia on auditory brainstem response of neonates treated with phototherapy. Iran J Otorhinolaryngol [Internet] 2016 Jan;28(84):23-9. Available from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4735613/
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.