Glottic carcinoma with anterior commissure involvement – Is understaging a reality?
DOI:
https://doi.org/10.34631/sporl.1024Keywords:
Carcinoma glótico, comissura anterior, recidiva, sobrevidaAbstract
Objectives: To determine if anterior commissure (AC) involvement in glottic cancer (GC) is a prognosis factor to recurrence and 5-year survival rate.
Study design: Observational retrospective. Methods: Assessment of medical files of patients who were diagnosed with GC with T1a and T1b staging during a 12-year period (2010-2021).
Results: Twenty-three patients (67,6%) were classified with T1a stage (10 cases with AC involvement) and 11 patients (32,4%) with T1b staging (7 cases with AC involvement). AC involvement was associated with higher risk of recurrence for T1b cases (p<0,05), but not for T1a cases. Five-year mortality rate had no significant statistically difference.
Conclusions: AC involvement was a negative prognostic factor in local disease control during follow-up, thus raising the possibility of AC inclusion in T staging in glottic tumors.
References
Ferlay J, Soerjomataram I, Dikshit R, Eser S, Mathers C, Rebelo M. et al. Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012. Int J Cancer. 2015 Mar 1;136(5):E359-86. doi: 10.1002/ijc.29210.
Rifai M, Khattab H. Anterior commissure carcinoma: I-histopathologic study. Am J Otolaryngol. Sep-Oct 2000;21(5):294-7. doi: 10.1053/ajot.2000.16159.
Rucci L, Gammarota L, Borghi Cirri MB. Carcinoma of the anterior commissure of the larynx: I. Embryological and anatomic considerations. Ann Otol Rhinol Laryngol. 1996 Apr;105(4):303-8. doi: 10.1177/000348949610500412.
Tulli M, Re M, Bondi S, Ferrante L, Dajko M. et al. The prognostic value of anterior commissure involvement in T1 glottic cancer: A systematic review and meta-analysis. Laryngoscope. 2020 Aug;130(8):1932-1940. doi: 10.1002/lary.28395.
Wu J, Zhao J, Wang Z, Li Z, Luo J, Liao B. et al. Study of the histopathologic characteristics and surface morphologies of glottic carcinomas with anterior vocal commissure involvement. Medicine (Baltimore). 2015 Jul;94(29):e1169. doi: 10.1097/MD.0000000000001169.
Hendriksma M, Sjögren EV. Involvement of the anterior commissure in early glottic cancer (Tis-T2): a review of the literature. Cancers (Basel). 2019 Aug 23;11(9):1234. doi: 10.3390/cancers11091234.
Rucci L, Gammarota L, Gallo O. Carcinoma of the anterior commissure of the larynx: II. Proposal of a new staging system. Ann Otol Rhinol Laryngol. 1996 May;105(5):391-6. doi: 10.1177/000348949610500512.
Piazza C, Filauro M, Paderno A, Marchi F, Perotti P, Morello R. et al. Three-dimensional map of isoprognostic zones in glottic cancer treated by transoral laser microsurgery as a unimodal treatment strategy. Front Oncol. 2018 May 22;8:175. doi: 10.3389/fonc.2018.00175.
Fleischer S, Pflug C, Hess M. Dipping and rotating: two maneuvers to achieve maximum magnification during indirect transnasal laryngoscopy. Eur Arch Otorhinolaryngol. 2020 May;277(5):1545-1549. doi: 10.1007/s00405-020-05862-7.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2022 Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.
