Variability of clear cell tumour presentation: case reports
DOI:
https://doi.org/10.34631/sporl.2082Keywords:
Head and neck cancer, clear cells, immunohistochemicalAbstract
Cancer significantly affects the world's population, and it was estimated in 2018 that Head and Neck Cancer would be the seventh most prevalent. Clear cells can be the result of different physiological processes and are found in various benign and malignant tumours. Although they are rare in head and neck tumours, they are mostly found in salivary glands. Clear cell tumours of the head and neck, namely Hyalinizing Clear Cell Carcinoma and Odontogenic Clear Cell Carcinoma are malignant tumours, morphologically and genetically similar, with functional, psychological, social and aesthetic impact on these patients. Histopathological and immunohistochemical tests are essential to distinguish clear cells lesions from other differential diagnoses. This work aims to demonstrate the clinical variability of presentation associated with the immunohistochemical overlap of these two types of clear cell tumours of the head and neck.References
Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018 Nov;68(6):394-424. doi: 10.3322/caac.21492.
Yang JY, Hwang DS, Kim UK. Sequential treatment from mandibulectomy to reconstruction on mandibular oral cancer – Case review II: Mandibular anterior and the floor of the mouth lesion of basaloid squamous cell carcinoma and clear cell odontogenic carcinoma. J Korean Assoc Oral Maxillofac Surg. 2021 Jun 30;47(3):216-223. doi: 10.5125/jkaoms.2021.47.3.216.
Woods T, Fitzpatrick S, Cohen D, Islam M, Bhattacharyya I. Clear cell changes in salivary gland neoplasms: a 20-year retrospective study. Med Oral Patol Oral Cir Bucal. 2017 May 1;22(3):e276-e281. doi: 10.4317/medoral.21570.
Premalatha BR, Rao RS, Patil S, Neethi H. Clear cell tumors of the head and neck: an overview. World J Dent. 2012; 3(4):344-349. doi: 10.5005/jp-journals-10015-1187.
Patankar S, Choudhari S, Sharma S, Dhumal S. Noncalcifying clear-cell variant of calcifying epithelial odontogenic tumor: a case report and review. J Oral Maxillofac Pathol. 2021 Jan-Apr;25(1):204. doi: 10.4103/jomfp.JOMFP_212_20.
Desai A, Faquin WC, Iafrate AJ, Rivera MN, Jaquinet A, Troulis MJ. Clear cell carcinoma: a comprehensive literature review of 254 cases. Int J Oral Maxillofac Surg. 2022 Jun;51(6):705-712. doi: 10.1016/j.ijom.2021.03.018.
Skalova A, Leivo I, Hellquist H, Simpson RHW, Vander Poorten V, Willems SM. et al. Clear cell neoplasms of salivary glands: a diagnostic challenge. Adv Anat Pathol. 2022 Jul 1;29(4):217-226. doi: 10.1097/PAP.0000000000000339.
Xuan L, Wang S, Wei J, Yuan J, Liu H. Clinicopathological and molecular study of 10 salivary gland clear cell carcinomas, with emphasis on rare cases with high grade transformation and occurring in uncommon sites. Diagn Pathol. 2022 Jan 30;17(1):18. doi: 10.1186/s13000-022-01200-z.
Albergotti WG, Bilodeau EA, Byrd JK, Mims MM, Lee S, Kim S. Hyalinizing clear cell carcinoma of the head and neck: case series and update. Head Neck. 2016 Mar;38(3):426-33. doi: 10.1002/hed.23902.
Weinreb I. Hyalinizing Clear cell carcinoma of salivary gland: a review and update. Head Neck Pathol. 2013 Jul;7 Suppl 1(Suppl 1):S20-9. doi: 10.1007/s12105-013-0466-8.
Nojima S, Kohara M, Harada H, Kajikawa H, Hirose K, Nakatsuka SI. et al. Clear cell carcinoma in the oral cavity with three novel types of EWSR1-ATF1 translocation: a case report. Head Neck Pathol. 2022 Jun;16(2):560-566. doi: 10.1007/s12105-021-01356-y.
Antonescu CR, Katabi N, Zhang L, Sung YS, Seethala RR, Jordan RC. et al. EWSR1-ATF1 fusion is a novel and consistent finding in hyalinizing clear-cell carcinoma of salivary gland. Genes Chromosomes Cancer. 2011 Jul;50(7):559-70. doi: 10.1002/gcc.20881.
Moro A, Gasparini G, Saponaro G, Barbera G, Doneddu P, Petrone G. et al. Clear cell odontogenic carcinoma: a case report and literature review. Oral Maxillofac Surg Cases. 2021 Jun 1;7(2): 100211 doi: 10.1016/j.omsc.2021.100211
Hansen LS, Eversole LR, Green TL, Powell NB. Clear cell odontogenic tumor-a new histologic variant with aggressive potential. Head Neck Surg. 1985 Nov-Dec;8(2):115-23. doi: 10.1002/hed.2890080208.
Loyola AM, Cardoso SV, de Faria PR, Servato JP, Barbosa de Paulo LF, Eisenberg AL. et al. Clear cell odontogenic carcinoma: report of 7 new cases and systematic review of the current knowledge. Oral Surg Oral Med Oral Pathol Oral Radiol. 2015 Oct;120(4):483-96. doi: 10.1016/j.oooo.2015.06.005
Guastaldi FPS, Faquin WC, Gootkind F, Hashemi S, August M, Iafrate AJ. et al. Clear cell odontogenic carcinoma: a rare jaw tumor. A summary of 107 reported cases. Int J Oral Maxillofac Surg. 2019 Nov;48(11):1405-1410. doi: 10.1016/j.ijom.2019.05.006.
Ullah A, Cullen C, Mattox SN, Kozman D, Patel N, Sharma S. et al. Clear cell Odontogenic carcinoma: a series of three cases. Dent J (Basel). 2022 Feb 25;10(3):34. doi: 10.3390/dj10030034.
Hadj Saïd M, Ordioni U, Benat G, Gomez-Brouchet A, Chossegros C, Catherine JH. Clear cell odontogenic carcinoma. A review. J Stomatol Oral Maxillofac Surg. 2017 Dec;118(6):363-370. doi: 10.1016/j.jormas.2017.08.005.
Ferreira S, Faverani LP, Santos GMD, Martins EP, Garcia Júnior IR. Clear cell odontogenic carcinoma of the mandible: a treatment strategy. J Appl Oral Sci. 2018 Jan 15;26:e20160645. doi: 10.1590/1678-7757-2016-0645.
Oliver J, Wu P, Chang C, Roden D, Wang B, Liu C. et al. Patterns of care and outcome of clear cell carcinoma of the head and neck. Otolaryngol Head Neck Surg. 2019 Jul;161(1):98-104. doi: 10.1177/0194599819835779.
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