Hearing loss in children with congenital cytomegalovirus infection

Authors

DOI:

https://doi.org/10.34631/sporl.2070

Keywords:

Cytomegalovirus, CMV, hearing, valganciclovir, children, screening

Abstract

Objective: To study the prevalence of hearing loss in children with congenital Cytomegalovirus infection and the influence of the type of maternal infection, symptoms and neonatal treatment with valganciclovir.
Study design: Retrospective cohort
Material and Methods: Data was collected through computerized processes of children with congenital Citomegalovirus, followed in Hospital de Guimarães, between 2017 and 2022. Hearing evaluation was performed between 2 months and 2 years old. The type of maternal infection and treatment with valganciclovir were assessed.
Results: Twenty-two children were enrolled in this study. Global prevalence of hearing loss was 50%, greater in symptomatic children and children born to mothers with primary infection. After treatment with valganciclovir, 41.6% of children presented with hearing loss.
Conclusion: The risk of hearing loss is greater in symptomatic children and children born to mothers with primary infection. A screening programme should be implemented regarding the high prevalence of hearing loss in asymptomatic children.

References

-Puhakka L, Lappalainen M, Lönnqvist T, Nieminen T, Boppana S, Saxen H. et al. Hearing outcome in congenitally CMV infected children in Finland – results from follow-up after three years age. Int J Pediatr Otorhinolaryngol. 2022 May;156:111099. doi: 10.1016/j.ijporl.2022.111099.

- Sousa SCG. Infecção congénita por citomegalovírus : importância da prevenção e diagnóstico precoce. [Tese de Mestrado na Internet]. [Lisboa]: Faculdade de Medicina; 2018. 28 p. Available from: https://repositorio.ul.pt/handle/10451/42570

- Chiopris G, Veronese P, Cusenza F, Procaccianti M, Perrone S, Daccò V. et al. Congenital cytomegalovirus infection: update on diagnosis and treatment. Microorganisms. 2020 Oct 1;8(10):1516. doi: 10.3390/microorganisms8101516.

- Riga M, Korres G, Chouridis P, Naxakis S, Danielides V. Congenital cytomegalovirus infection inducing non-congenital sensorineural hearing loss during childhood; a systematic review. Int J Pediatr Otorhinolaryngol. 2018 Dec;115:156-164. doi: 10.1016/j.ijporl.2018.10.005.

- Goderis J, De Leenheer E, Smets K, Van Hoecke H, Keymeulen A, Dhooge I. Hearing Loss and Congenital CMV infection: a systematic review. Pediatrics. 2014 Nov;134(5):972-82. doi: 10.1542/peds.2014-1173. Pediatrics 2014;134:972–82. https://doi.org/10.1542/peds.2014-1173.

- Kenneson A, Cannon MJ. Review and meta-analysis of the epidemiology of congenital cytomegalovirus (CMV) infection. Rev Med Virol. 2007 Jul-Aug;17(4):253-76. doi: 10.1002/rmv.535.

- Palma S, Roversi MF, Bettini M, Mazzoni S, et al. Hearing loss in children with congenital cytomegalovirus infection: an 11-year retrospective study based on laboratory database of a tertiary paediatric hospital. Acta Otorhinolaryngol Ital. 2019 Feb;39(1):40-45. doi: 10.14639/0392-100X-2020.

- Fowler KB, Boppana SB. Congenital cytomegalovirus (CMV) infection and hearing deficit. J Clin Virol. 2006 Feb;35(2):226-31. doi: 10.1016/j.jcv.2005.09.016

- Singh G, Gaidhane A. A review of sensorineural hearing loss in congenital cytomegalovirus Infection. Cureus. 2022 Oct 26;14(10):e30703. doi: 10.7759/cureus.30703

- Kimberlin DW, Jester PM, Sánchez PJ, Ahmed A, et al. Valganciclovir for symptomatic congenital cytomegalovirus disease. N Engl J Med. 2015 Mar 5;372(10):933-43. doi: 10.1056/NEJMoa1404599.

- Cannon MJ, Griffiths PD, Aston V, Rawlinson WD. Universal newborn screening for congenital CMV infection: what is the evidence of potential benefit? Rev Med Virol. 2014 Sep;24(5):291-307. doi: 10.1002/rmv.1790.

- Ross SA, Ahmed A, Palmer AL, Michaels MG, Sánchez PJ, Bernstein DI. et al. Detection of congenital cytomegalovirus infection by real-time polymerase chain reaction analysis of saliva or urine specimens. J Infect Dis. 2014 Nov 1;210(9):1415-8. doi: 10.1093/infdis/jiu263

- Chen K, Zhong Y, Gu Y, Sharma R, Li M, Zhou J. et al. Estimated cost-effectiveness of newborn screening for congenital cytomegalovirus infection in China using a Markov Model. JAMA Netw Open. 2020 Dec 1;3(12):e2023949. doi: 10.1001/jamanetworkopen.2020.23949.

- Mareri A, Lasorella S, Iapadre G, Maresca M, Tambucci R, Nigro G. Anti-viral therapy for congenital cytomegalovirus infection: pharmacokinetics, efficacy and side effects. J Matern Fetal Neonatal Med. 2016;29(10):1657-64. doi: 10.3109/14767058.2015.1058774

Published

2023-11-06

How to Cite

Caetano Oliveira, G., Morgado, F., Santos, M., Mota, C., Matos, R., Robles, R., & Fonseca, R. (2023). Hearing loss in children with congenital cytomegalovirus infection. Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery, 61(3), 293–297. https://doi.org/10.34631/sporl.2070

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Section

Original Article