The impact of pharyngocutaneous fistula on the survival of patients submitted to total laringectomy
DOI:
https://doi.org/10.34631/sporl.2047Keywords:
Faringocutaneous Fistula, Total laryngectomy, SurvivalAbstract
Objectives: The pharingocutaneous fistula (FFC) is an important post-operatory complication after total laryngectomy (LT), often associated with an increase in peri-operatory morbidity. Studies about the impact of FFC on long-term survival on patients submitted to LT remain scarce. The objective of this work was to study the relation between the presence of FFC and the survival rate of patients submitted to total laryngectomy.Material and methods: A retrospective cohort study was performed on patients submitted to LT between January 2013 and December 2017. The evaluation of survival and associated risk was preformed through a Kaplan-Meier analysis and multivariate Cox regression. Results: 50 patients were included, with an average follow-up time of 67 months. The overall survival and disease-free survival were similar between the two groups, with no significant statistical difference.
Conclusions: Our study didn’t find any relation between the presence of FFC and the survival rates of patients submited to LT.
References
Wang M, Xun Y, Wang K, Lu L, Yu A, Guan B. et al. Risk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis. Eur Arch Otorhinolaryngol. 2020 Feb;277(2):585-599. doi: 10.1007/s00405-019-05718-9.
Rao KN, Arora RD, Singh A, Nagarkar NM, Aggarwal A. Pharyngocutaneous fistula following primary total laryngectomy: a meta-analysis. Indian J Surg Oncol. 2022 Dec;13(4):797-808. doi: 10.1007/s13193-022-01581-z.
Busoni M, Deganello A, Gallo O. Pharyngocutaneous fistula following total laryngectomy: analysis of risk factors, prognosis and treatment modalities. Acta Otorhinolaryngol Ital. 2015 Dec;35(6):400-5. doi: 10.14639/0392-100X-626.
Dedivitis RA, Aires FT, Cernea CR, Brandao LG. Pharyngocutaneous fistula after total laryngectomy: systematic review of risk factors. Head Neck. 2015 Nov;37(11):1691-7. doi: 10.1002/hed.23804.
Michael RC, Das S, Mani S, Arunagiri S, Thomas R, Vediappan RS. et al. Pharyngocutaneous fistula following primary and salvage laryngectomy: aetiology and predictive factors. Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):2139-2148. doi: 10.1007/s12070-020-02046-x.
Davies JC, Hugh S, Rich JT, de Almeida JR, Gullane PJ, Orsini M. et al. Association of pharyngocutaneous fistula with cancer outcomes in patients after laryngectomy: a multicenter collaborative cohort study. JAMA Otolaryngol Head Neck Surg. 2021 Dec 1;147(12):1027-1034. doi: 10.1001/jamaoto.2021.1545.
Kim YH, Roh JL, Choi SH, Nam SY, Kim SY. Prediction of pharyngocutaneous fistula and survival after salvage laryngectomy for laryngohypopharyngeal carcinoma. Head Neck. 2019 Sep;41(9):3002-3008. doi: 10.1002/hed.25786.
Edge SB, Compton CC. The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol. 2010 Jun;17(6):1471-4. doi: 10.1245/s10434-010-0985-4.
von Elm E, Altman DG, Egger M, Pocock SJ, Gøtzsche PC, Vandenbroucke JP. et al. The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies. Epidemiology. 2007 Nov;18(6):800-4. doi: 10.1097/EDE.0b013e3181577654.
Kim DH, Kim SW, Hwang SH. Predictive value of risk factors for pharyngocutaneous fistula after total laryngectomy. Laryngoscope. 2023 Apr;133(4):742-754. doi: 10.1002/lary.30278.
Chotipanich A, Wongmanee S. Incidence of pharyngocutaneous fistula after total laryngectomy and its relationship with the shapes of mucosa closure: a meta-analysis. Cureus. 2022 Sep 6;14(9):e28822. doi: 10.7759/cureus.28822.
Cohen J, Reed W, Foster MW, Kahmke RR, Rocke DJ, Puscas L. et al. Octreotide may improve pharyngocutaneous fistula healing through downregulation of cystatins: A pilot study. Laryngoscope Investig Otolaryngol. 2022 Nov 28;8(1):113-119. doi: 10.1002/lio2.962.
Gonzalez-Marquez R, Rodrigo JP, Suarez Nieto C. Prognostic significance of postoperative wound infections after total laryngectomy. Head Neck. 2012 Jul;34(7):1023-7. doi: 10.1002/hed.21866.
Penel N, Fournier C, Roussel-Delvallez M, Lefebvre D, Kara A, Mallet Y. et al. Prognostic significance of wound infections following major head and neck cancer surgery: an open non-comparative prospective study. Support Care Cancer. 2004 Sep;12(9):634-9. doi: 10.1007/s00520-004-0600-y.
Penel N, Fournier C, Lefebvre D, Lefebvre JL. Multivariate analysis of risk factors for wound infection in head and neck squamous cell carcinoma surgery with opening of mucosa. Study of 260 surgical procedures. Oral Oncol. 2005 Mar;41(3):294-303. doi: 10.1016/j.oraloncology.2004.08.011.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2023 Portuguese Journal of Otorhinolaryngology and Head and Neck Surgery
![Creative Commons License](http://i.creativecommons.org/l/by-sa/4.0/88x31.png)
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License.